NovaPep

Buy Cagrilintide Australia: Cagrilintide 5mg and 10mg Research Vials

$69AUD, GST included

In stock in Australia, batch certificate ready

Certificate of analysis published for every batch
Third-party HPLC purity and MS identity testing
Dispatched same day before 3pm cut-off, tracked Australia-wide
Research use only, sold to adults aged 18 and over

Buy cagrilintide online in Australia in 5 mg and 10 mg research vials, tested for identity and purity on every lot. Cagrilintide is a long-acting amylin analogue that Novo Nordisk created under the code NN9838, acylated so it binds albumin and lasts around a week instead of minutes. It activates the amylin receptors, formed from the calcitonin receptor combined with RAMP proteins, as well as the calcitonin receptor on its own. We hold it in local stock as 5 mg and 10 mg lyophilised vials for delivery anywhere in Australia, listed in our metabolic peptides range. Compare your lot with the reference identity, formula C194H312N54O59S2, roughly 4409 g/mol and CAS 1415456-99-3. Every lot is examined by mass spectrometry for identity and HPLC for purity, and the certificate can be read before checkout. Since cagrilintide peptide carries no GLP-1 activity, researchers frequently add tirzepatide to the same order so incretin and amylin signalling can be studied in parallel. Powder is all that ships in the vial, so include bacteriostatic water, and use the peptide calculator to turn any water volume into a concentration. Hold the sealed vial dry and dark at -20 °C. Supplied as a research reagent to adults 18 and over for in vitro work only.

For laboratory research use only. Not for human or veterinary use. Not TGA approved. See the NovaPep research use policy.

Cagrilintide Explained: A Long-Acting Amylin Analogue

Cagrilintide is a long-lived synthetic form of amylin, the pancreatic hormone that slows digestion and signals fullness after eating. Natural amylin lasts only minutes, whereas the cagrilintide peptide was engineered to remain active across days. That converted an unwieldy hormone into a workable research tool. Buy Cagrilintide online in Australia as a 5 mg or 10 mg research vial, with the lot certificate published before you order.

Amylin is a 37 amino acid peptide secreted by pancreatic beta cells together with insulin. In its natural state it clears within minutes and tends to aggregate at the bench. The native human peptide also misfolds easily into amyloid fibrils, the very deposits seen in many type 2 diabetic pancreases, and that fact alone ruled it out as a practical molecule.

Where Cagrilintide Comes From

The molecule emerged from Novo Nordisk's obesity research in Denmark, where chemists aimed to produce an amylin analogue lasting days instead of minutes. Their development paper in the Journal of Medicinal Chemistry in 2021 sets out the sequence changes and acylation that make that possible.

Pramlintide was the first solution to the fibril problem, substituting prolines at positions 25, 28 and 29. Those were taken from the rat sequence because rat amylin does not form fibrils. It did the job but cleared rapidly and acts only briefly. The chemists at Novo Nordisk retained the anti-fibril approach and also fixed the clearance issue.

Inside the Cagrilintide Molecule

Cagrilintide retains the disulfide-bridged ring near the N-terminus on which amylin depends for receptor activity. It includes substitutions that cut the fibril formation seen with the native hormone. It also carries an attached lipid chain for albumin binding, giving a half-life of roughly a week in published work.

Cagrilintide at a Glance

Parent hormone: amylin, a 37 amino acid peptide released with insulin
Developer: Novo Nordisk, under the code NN9838
Key changes: anti-fibril substitutions plus a fatty acid chain that binds albumin
Half-life: around a week in published work
Receptors: AMY1, AMY2, AMY3 and the calcitonin receptor alone

The Science Behind Cagrilintide: Amylin and Calcitonin Receptors

The everyday role of amylin is easily missed because insulin takes the spotlight. Released alongside insulin, it acts on the hindbrain and particularly the area postrema, a region that lies outside the blood-brain barrier and samples signals in the circulation. From there it slows gastric emptying, dampens the glucagon rise that would otherwise follow eating and reduces meal size. In short, it partners with insulin to keep glucose from rising too quickly after a meal. To run this kind of in vitro work, buy Cagrilintide online in Australia from lots tested by HPLC and mass spectrometry.

Its target receptors consist of the calcitonin receptor coupled with a receptor activity-modifying protein, either RAMP1, RAMP2 or RAMP3. The three amylin receptor subtypes are AMY1, AMY2 and AMY3, each pairing a calcitonin receptor (CTR) with one RAMP. Published binding work shows cagrilintide activating all three along with CTR alone, which is the reason technical sheets describe it as non-selective.

It has no GLP-1 or GIP activity. That clean separation from the incretin system is what makes it useful in metabolic research.

What Cagrilintide Research Has Found

The weekly analogue progressed into human trials. The phase 2 dose-finding study led by David Lau (The Lancet, 2021) randomised 706 adults to placebo, liraglutide or one of five cagrilintide doses across 26 weeks. Mean weight loss reached 10.8% in the top cagrilintide dose group, against 9.0% on liraglutide and 3.0% on placebo.

The much bigger REDEFINE 1 trial (NEJM, 2025) ran 68 weeks with 3,417 adults and combined cagrilintide with semaglutide. The combination arm showed a 20.4% reduction compared with 3.0% on placebo. Research units and hospitals in Australia have joined the trials, among them REDEFINE 1 and REIMAGINE 2 in type 2 diabetes. These figures are clinical results cited as published research, not claims concerning this vial.

Cagrilintide in a Cell Assay

So what does cagrilintide do in a cell assay? More than most people expect, the answer depends on the cells, and this is where we see the most avoidable confusion. Because it activates bare calcitonin receptors as well as the RAMP-paired amylin receptors, a response in any given line means little until you establish which RAMPs that line expresses.

We suggest profiling it first in matched lines, the calcitonin receptor alone versus the same receptor co-expressed with RAMP1 or RAMP3. Do this before drawing conclusions from a combination experiment involving an incretin agonist. Without that baseline, a calcitonin effect and an amylin effect appear the same on the plate.

The research question states itself simply. What does prolonged amylin receptor activation deliver by itself, and what does it contribute when an incretin agonist is also present?

Reading the Cagrilintide Evidence

Unusually for a research peptide, cagrilintide has large published human trials behind it. Those trials answer clinical questions about weight, not mechanistic ones about receptors. At the bench the open questions are narrower. Which receptor subtype carries a given response, and how does amylin signalling add to incretin signalling in the same cell? Matched receptor lines are the tool that answers both.

Cagrilintide Specifications

Compound	Cagrilintide (NN9838)
Sizes	5 mg vial and 10 mg vial
Structure	An acylated long-acting amylin analogue acting as a non-selective agonist at calcitonin and amylin receptors
Formula	C194H312N54O59S2
Molar mass	Roughly 4409 g/mol
CAS	1415456-99-3
Physical form	Lyophilised cagrilintide powder sealed in a glass vial
Lot testing	Purity by HPLC and identity by mass spectrometry, with a certificate of analysis for each lot
In the box	One vial of lyophilised cagrilintide at either 5 mg or 10 mg, with bacteriostatic water available separately
Storage	Sealed vial dry and dark at -20 °C, and solutions held at 2 to 8 °C
Stock status	In stock
Intended use	In vitro laboratory research only

The two fills look distinct. The 5 mg vial carries a white label with a green flip-off cap. The 10 mg vial has a white cap with a pink and blue label. Both hold white lyophilised cagrilintide powder to the same specification with nothing added.

On the certificate, check for a measured mass close to 4409 g/mol, a lot code matching your label and the HPLC purity reported for that lot. All reports are stored in our COA library, downloadable before or after you order.

Storing and Reconstituting Cagrilintide

Add bacteriostatic water to the order, as the vial holds powder alone. Allow the glass to warm to room temperature, run the water slowly down the wall and swirl until the solution clears. Our guide on how to reconstitute peptides covers each step. Adding 2 mL to the 5 mg vial yields 2.5 mg/mL, while the same 2 mL in the 10 mg vial yields 5 mg/mL. Small volumes are simplest to measure with insulin syringes. When you buy Cagrilintide online in Australia, orders paid by 3pm on a business day are dispatched the same afternoon.

Keep the unopened cagrilintide vial at -20 °C. After mixing, store it at 2 to 8 °C out of the light, split it into aliquots and steer clear of repeated freeze and thaw cycles. Aim to finish a mixed solution within the usual 28 day window.

Cagrilintide Compared With Tirzepatide

Each addresses a different question. Cagrilintide acts via calcitonin and amylin receptors with no incretin activity, whereas tirzepatide hits the GLP-1 and GIP receptors and leaves amylin receptors untouched. Use cagrilintide for amylin pathway studies, tirzepatide for incretin studies, and both when your design examines how the two systems work together.

For a third axis, retatrutide brings the glucagon receptor into the incretin side, and any cagrilintide lot can be run against it in the same assay. Labs running combination studies sometimes use an incretin reference such as the pre-filled tirzepatide pen.

Other Names for Cagrilintide

The compound is listed as cagrilintide, under the code NN9838 and, in a few early papers, as AM833. It is also referred to as an acylated amylin analogue, a long-acting amylin analogue or a dual amylin and calcitonin receptor agonist, often abbreviated to DACRA.

CagriSema is the name for a combination of cagrilintide with semaglutide studied in clinical programmes. It is neither a distinct molecule nor what this vial holds. Amylin itself also goes by islet amyloid polypeptide, or IAPP.

Buy Cagrilintide Online in Australia

Cagrilintide remains investigational. Novo Nordisk's lead programme combines it with semaglutide as CagriSema, and the company lodged a US new drug application for that combination in December 2025. Taking part in a trial is not registration. As at October 2026 we found no cagrilintide-containing product on the ARTG, so no Australian prescriber can order it as an approved medicine and no pharmacy holds it, either alone or in the combination.

That gap explains why cagrilintide for sale in Australia comes through research suppliers rather than the medicines chain. NovaPep keeps both fills in Australian stock as a laboratory reagent, open to online ordering by adults 18 and over and never for veterinary or human use. The vial is a research reagent with no connection to any approved medicine, and each lot report is in the certificate archive before you order.

The 5 mg vial makes the sensible first purchase. Most cagrilintide work is combination research, and the ratio against the partner compound is seldom settled at the first attempt, so a smaller fill wastes less. The 10 mg vial is the better value fill for a finalised protocol. Both share the same specification, so switching sizes changes the number of reconstitutions, not the compound.

There is nowhere to visit in person, even for labs seeking peptides in Canberra. NovaPep trades online only and sends every cagrilintide Australia order from local stock to regional and metro addresses alike. Payment received before 3pm on a business day is dispatched the same day, as described on our delivery information page. For a lengthy series, order several vials from one lot where stock allows.

Cagrilintide at a Glance

Amylin analogue that lasts

An acylated version of the hormone released with insulin, stabilised against aggregation and albumin-bound for a half-life of around a week.

Amylin and calcitonin receptors

It activates all three RAMP-paired amylin receptors plus the calcitonin receptor alone, so it is described as non-selective.

Bench use only

Calcitonin and amylin receptor pharmacology, either alone or in combination designs alongside incretin agonists, strictly in the laboratory.

Compared with tirzepatide

It has no GIP or GLP-1 activity whatsoever, and that clean separation is why the two so often travel together.

Freezer, then fridge

Sealed vial at -20 °C and solution at 2 to 8 °C in aliquots, with repeated freeze and thaw avoided.

Order 5 mg or 10 mg

Two lyophilised fills from Australian stock, each lot tested by HPLC and mass spectrometry. Add bacteriostatic water to the cart.

Cagrilintide FAQ

Why do laboratories use cagrilintide?

It serves as a stable, long-acting means of activating amylin receptors and the calcitonin receptor in receptor and cell assays. Labs use it either to separate amylin signalling from incretin signalling or to examine both at once. It is sold purely for in vitro research, never for animals or people.

How does cagrilintide differ from natural amylin?

Native amylin clears within minutes and readily forms amyloid fibrils. Cagrilintide keeps the disulfide ring amylin needs for receptor activity, adds substitutions that reduce fibril formation and carries a lipid chain that binds albumin. Published work gives it a half-life of around a week.

Which fits my study, cagrilintide or tirzepatide?

Take cagrilintide for calcitonin and amylin receptor studies, as it has no incretin activity. Take tirzepatide for GLP-1 and GIP receptor work. Where the question concerns how both hormone systems interact, buy the two and run them in one design using matched lots.

Is a certificate of analysis supplied with cagrilintide?

It is. Each lot undergoes identity testing by mass spectrometry and purity testing by HPLC prior to release. The certificate sits in our COA library under the lot code on your vial, so it can be reviewed before you order and filed with your records.

What size of cagrilintide makes the best first order?

Begin with the 5 mg vial. Combination studies generally take a few rounds before the ratio against the partner compound settles, and a smaller fill is easier to finish inside 28 days of mixing. Shift to the 10 mg vial once your protocol is locked in.

What is the way to order cagrilintide online in Australia?

Pick either the 5 mg vial or the 10 mg vial on this page and add it to your cart. Clear payment ahead of the 3pm business-day cut-off and your parcel leaves our Australian stock that afternoon, to every state and territory. Include bacteriostatic water in the order, since the vial contains powder only.