KPV 10 mg lyophilised peptide vial with blue flip-off cap and white label

NovaPep

Buy KPV Peptide Australia: KPV 10mg Research Vial (Lysine-Proline-Valine)

$59AUD, GST included

In stock in Australia, batch certificate ready

Size: 10 mg vial

Certificate of analysis published for every batch
Third-party HPLC purity and MS identity testing
Dispatched same day before 3pm cut-off, tracked Australia-wide
Research use only, sold to adults aged 18 and over

Buy KPV peptide online in Australia as a 10 mg research vial of lysine-proline-valine, tested for identity and purity on every lot. KPV is lysine-proline-valine, the tripeptide at the C-terminal end of alpha-MSH. It lacks the His-Phe-Arg-Trp core that activates melanocortin receptors, so labs use it to study inflammatory signalling in epithelial cells rather than pigmentation. Because it has just three residues its identity is simple to confirm, with formula C16H30N4O4, a molar mass of 342.4 g/mol and CAS 67727-97-3. Before release, mass spectrometry confirms each lot and HPLC measures its purity. The peptide calculator converts any volume of diluent into mg per mL. Many buyers also add BPC-157, which is studied in related gut lining models but through very different pathways. There is no diluent in the vial, only dry powder, so include bacteriostatic water in your order. Store the unopened KPV vial frozen, dry and dark at -20 °C. This lab reagent is supplied only to adults aged 18 and over.

For laboratory research use only. Not for human or veterinary use. Not TGA approved. See the NovaPep research use policy.

What Is KPV Peptide?

KPV is a three amino acid peptide of lysine, proline and valine, the last three residues of alpha-MSH (alpha-melanocyte-stimulating hormone). Researchers study it because it retains a large part of that hormone's anti-inflammatory activity while leaving out its pigmentation role. Alpha-MSH has 13 residues and is cleaved from a bigger precursor, pro-opiomelanocortin (POMC), which is processed by cells in the skin, the pituitary and the immune system. The native hormone has an amidated valine end, whereas the research tripeptide we sell is the free acid, the form used in most cell studies. Buy KPV online in Australia as a 10 mg research vial, with the lot certificate published before you order.

Hiltz and Lipton in the United States first described the anti-inflammatory effect of this alpha-MSH tail in 1989, showing that the 11 to 13 fragment lessened swelling in a mouse ear inflammation model. Over thirty years on, the tripeptide remains a research tool. The same molecule is one of the four ingredients in the KLOW blend for labs that use the complete combination.

How KPV Works From Inside the Cell

Most peptides we stock work by attaching to a receptor on the outside of the cell, but KPV appears to act from within. Alpha-MSH signals via melanocortin receptors, yet a 2008 Gastroenterology paper by Guillaume Dalmasso, Didier Merlin and colleagues showed that KPV produced no cAMP rise in Caco-2 intestinal cells, even though those cells carry two such receptors, MC3R and MC5R. The key was PepT1, a transporter that usually draws dietary di- and tripeptides into the lining of the small intestine and is more plentiful in an inflamed colon. After being carried into the cell, KPV at 10 nanomolar reduced NF-kappa B activation and the phosphorylation of three MAP kinases (ERK1/2, JNK and p38), and the cells secreted less IL-8, a chemokine that attracts neutrophils to inflamed tissue. Swamping the transporter with a competing dipeptide, glycyl-leucine, removed the effect entirely.

One thing we would urge every lab to do is confirm PepT1 expression in its cell line before building a study around KPV. A line with little or no transporter may give a weak or missing response that reflects poor uptake rather than the peptide itself. A quick check of PepT1 levels plus a Gly-Leu competition arm can prevent a puzzling first run.

KPV Research: What Studies Have Looked At

Mouse models used in the paper were DSS colitis across 8 days and TNBS colitis, with KPV supplied at 100 micromolar in the drinking water.
Endpoints measured were colon histology, weight loss, cytokine levels and myeloperoxidase activity.
In later work the Merlin group packaged KPV in colon-targeted nanoparticles so that smaller amounts could reach inflamed tissue.

Keratinocytes have their own melanocortin machinery and inflammatory cascades, which makes skin cells the second main setting for this compound and the foundation of most KPV peptide anti-inflammatory skin research. All findings to date are preclinical, and what we supply is a reagent for repeating and building on that work. You can find other inflammation tools in our immune research peptides. To run this kind of in vitro work, buy KPV online in Australia from lots tested by HPLC and mass spectrometry.

KPV is a small, easily checked tool for studying the anti-inflammatory signalling it inherits from alpha-MSH, without switching on pigmentation receptors. Researchers apply it in keratinocyte and intestinal cell lines and in rodent colitis models. Every vial is supplied for bench and in vitro research and never for human or veterinary use.

Gut and skin cell research

Studies of KPV peptide for skin models rely on keratinocyte cultures and topical inflammation work in rodents, where NF-kappa B activity and cytokine release are the standard readouts. Gut studies instead lean on colitis models and Caco-2 monolayers. In both areas the tripeptide is treated as a probe of inflammatory signalling and not as a finished product, and every result to date comes from animals and cells. Any KPV peptide skin benefits reported so far are lab measurements, such as reduced cytokine output from cultured keratinocytes and lower inflammation scores in rodent skin. Our guide to skin research peptides sets them beside other compounds used in skin models.

KPV Specifications

Product name	KPV (lysyl-prolyl-valine)
Size	10 mg lyophilised vial
Sequence	Lys-Pro-Val, alpha-MSH residues 11 to 13
Residues	3 amino acids
Formula	C16H30N4O4
Molecular weight	342.4 g/mol
CAS	67727-97-3
Presentation	Sealed 3 mL glass vial of white lyophilised powder
Quality checks	Mass spectrometry for identity, HPLC for purity, lot certificate available online
In the box	One 10 mg KPV vial supplied dry, with bacteriostatic water bought separately
Storage conditions	Unopened at -20 °C away from light and moisture, then 2 to 8 °C once dissolved
Stock status	In stock
Intended purpose	Strictly in vitro laboratory research

KPV suits studies of inflammatory signalling in epithelial cells. It has only three residues, is straightforward to synthesise and its identity can be checked by anyone reading the certificate. At 342 g/mol a 10 mg vial contains around 29 micromoles, enough for a long series of experiments at modest cost.

In a chain of three amino acids, a missing or swapped residue gives a powder that looks identical, so the mass result is what really matters. Your certificate should report a measured mass close to 342.4 g/mol and an HPLC chromatogram with a single main peak, with the purity figure printed next to it. Each of the three residues is in the L form, with a free amine at the N-terminus and a free acid at the C-terminus.

Review that data, which is stored by lot code in our certificate of analysis library, and check it against the label when the vial arrives.

Purity is also easier to read for short peptides. A sequence this brief has only a few likely impurities, for example a deletion dipeptide or a racemised valine, and these resolve cleanly from the main peak on a reversed-phase column. As a result KPV is among the easiest compounds we sell to describe in a methods section, and a good first buy for a lab building its own identity checks on incoming reagents. It also settles which is the best KPV peptide to keep on hand, because the one you can verify line by line is the one worth stocking.

An independent lab tests every lot, using mass spectrometry to confirm a mass near 342.4 g/mol and HPLC to measure purity. With a sequence of just three residues, the mass result is the true proof of identity. Find the report in our COA library using the lot code printed on your vial.

Handling and Storage of KPV

Add bacteriostatic water for reconstitution to the same cart, since KPV is hydrophilic and dissolves easily. Allow the vial to reach room temperature, run the diluent down the glass and rotate it gently. Using 2 mL in the 10 mg vial gives 5 mg/mL, and the peptide reconstitution calculator handles all other volumes. When you buy KPV online in Australia, orders paid by 3pm on a business day are dispatched the same afternoon.

Store the dry powder dark and dry at -20 °C. After dissolving, keep it at 2 to 8 °C in aliquots so the stock solution is not repeatedly warmed and cooled.

KPV Compared With BPC-157 and the KLOW Blend

Both appear in intestinal models, so labs often weigh them up before ordering. BPC-157 peptide has fifteen residues, comes from a gastric protein and is studied in rodents for tissue repair, nitric oxide and angiogenesis. KPV, in contrast, is a hormone-derived tripeptide used to investigate inflammatory signalling inside epithelial cells. Choose KPV when the question is about cytokines and barrier cells, and BPC-157 when it is about healing tissue and blood supply.

Choose the KLOW four-peptide blend if a protocol is already set at its ratio, as KPV is one of its four ingredients. To study the tripeptide by itself, the single vial is the right choice.

Choose the single KPV vial when KPV is the compound you need to measure or vary. KLOW only makes sense when your protocol already combines KPV with GHK-Cu, BPC-157 and TB-500 at the blend ratio, since blended peptides can never be pulled apart again.

Other Names for KPV

This tripeptide may be written as alpha-MSH (11-13), lysyl-prolyl-valine, H-Lys-Pro-Val-OH, Lys-Pro-Val or simply KPV. Some papers call it the C-terminal tripeptide of alpha-MSH. Every one of these names refers to the chain with formula C16H30N4O4 and CAS 67727-97-3.

Associated terms come from its biology, among them IL-8, NF-kappa B, PepT1 (SLC15A1), melanocortin and POMC. Do not mistake KPV for the melanotan analogues, which keep the receptor-activating core that KPV does not have.

Buy KPV Online in Australia, the Vial and Its Legal Status

We send a 3 mL glass vial holding 10 mg of fine white powder and nothing else.

There is one size, the 10 mg vial, one of the cheapest per milligram across our recovery research peptides. As the molecule is so small, each milligram provides far more moles than the same weight of a longer peptide.

Buy several vials at once and they will come from one lot where stock permits, which takes away a variable between two experimental series. We sell KPV only to adults 18 or older, who confirm their age and a laboratory purpose at checkout.

What is the legal position of KPV in Australia?

The true answer is more limited than many listings suggest. As of October 2026 KPV has no approved therapeutic use in Australia, and unlike BPC-157 or TB-500 we could not find a specific named entry for it in the Poisons Standard. That absence does not turn it into a consumer product. The TGA's April 2026 advisory on unapproved peptide products, and its guidance that labelling goods as research only does not alter the law when they are supplied for people, cover any peptide offered for human use. Athletes have a separate rule to follow, because WADA's S0 category captures pharmacological substances lacking current government approval for human therapeutic use.

KPV peptide Australia listings are therefore research supply and nothing more. NovaPep holds the 10 mg vial in Australian stock as a lab reagent that adults 18 and over can order online, and it is never for human or veterinary use. If you intend to buy KPV in Australia for a combined protocol, compare it first with the KLOW peptide blend 80 mg, and look up the lot in our COA archive before you order.

There is no need to track down a KPV stockist in your own city or go looking for peptides on the Gold Coast. Our online store serves research teams all over Australia from one local stock, and orders placed before the 3pm cut-off on a working day ship that same day with tracking. State-by-state delivery details are listed on our shipping page.

KPV at a Glance

Lys, Pro and Val

KPV is a very small three amino acid peptide taken from the tail of the hormone alpha-MSH. It is produced by chemical synthesis and dried into a stable powder.

A single 10 mg vial

Buy a single sealed glass vial containing 10 mg of powder. The solvent is not included and can be ordered from our laboratory supplies.

Inflammatory signals in gut cells

Researchers apply it to cultured skin or intestinal cells, or test it in mouse colitis models, to see how inflammatory signals turn on and off. This is basic research only.

KPV compared with BPC-157

BPC-157 is studied in the gut as well, but it is five times longer and comes from a stomach protein. KPV derives from a hormone and probes different mechanisms.

Keep it cold and use it promptly

Freeze the powder and refrigerate the dissolved solution, using it within weeks. The online calculator helps avoid concentration mistakes.

Certificate for each lot

Every lot is tested by HPLC and mass spectrometry, and you can open the report using the lot number printed on the vial.

KPV FAQ

What exactly is KPV peptide?

KPV is the tripeptide lysine, proline, valine, taken from the C-terminal end of alpha-MSH and sold here as a 10 mg vial. It lacks the melanocortin core that drives pigmentation, so labs use it to study inflammatory signalling in gut and skin cells.

How does KPV work in research models?

KPV does not appear to act through melanocortin receptors on the cell surface. In Caco-2 intestinal cells it is carried inside by the PepT1 transporter, where it reduced NF-kappa B activation, MAP kinase phosphorylation and IL-8 secretion. Blocking PepT1 with a competing dipeptide removed the effect.

Which KPV peptide benefits have laboratories reported?

Reports of KPV peptide benefits (gut, skin, inflammation) are all preclinical. In intestinal and keratinocyte cell lines and in mouse colitis models, KPV has lowered markers of inflammatory signalling, including cytokine release and NF-kappa B activity. None of this shows any effect in humans, and the vial is sold only as a reagent for repeating and extending that lab research.

Is there a KPV peptide topical skin inflammation study?

Yes, in the lab. A KPV peptide topical skin inflammation study typically works in cultured keratinocytes or rodent skin models, measuring cytokine markers rather than visible results in people. We make no cosmetic or medical claims, and our vial is a research reagent only.

What is the KPV peptide dosage?

NovaPep provides no KPV dosage for people or animals, because the tripeptide is sold for in vitro research only. Questions about a KPV peptide dosage for personal use are outside our role. For cell work, the peptide calculator converts the 10 mg vial and any diluent volume into mg per mL.

How do I order KPV online in Australia?

Put the 10 mg vial in your cart and finish checkout on this page. We hold stock locally, and orders placed before 3pm on a business day leave that afternoon with tracking. The vial holds powder only, so add bacteriostatic water if required, and confirm that you are 18 or over.