What Is SLU-PP-332? A Guide to the Exercise Mimetic Compound
SLU-PP-332 is a lab-made small molecule that activates all three estrogen-related receptors, ERR alpha, beta and gamma. Cells rely on these receptors to build new mitochondria after endurance exercise. The compound came out of Thomas Burris's laboratory at Saint Louis University, and in mice it boosted endurance and cut fat mass. Nobody has tested it in humans, and although the name suggests otherwise, it is not a peptide.
Buy SLU-PP-332 Australia Labs Use, Knowing It Is Not a Peptide
Plenty of people call it the slu pp 332 peptide, but that label is inaccurate. SLU-PP-332 contains no amino acids whatsoever. It is an acyl hydrazone made from 4-hydroxybenzoic hydrazide and 2-naphthaldehyde, with the formula C18H14N2O2, a molecular weight of roughly 290 and the CAS number 303760-60-3. To put that in context, MOTS-c, a 16-residue peptide, weighs about seven times as much. The SLU in the name stands for Saint Louis University, where the Burris group carried out the medicinal chemistry.
It lands in peptide catalogues because the labs studying it are the same labs studying mitochondrial and metabolic peptides. Grouping them makes sense for research, yet it leads some suppliers to describe SLU-PP-332 in peptide terms that do not apply. The chemistry affects handling too. Dissolved, a small aromatic compound does not act like a peptide, and the usual practical limit is solubility rather than enzymatic breakdown. You can buy SLU-PP-332 online in Australia as a 5 mg vial or 60 capsules.
Order SLU-PP-332 Online and Understand Its Target, the Estrogen-Related Receptors
The name is misleading here as well, because estrogen-related receptors do not bind estrogen. ERR alpha, beta and gamma are orphan nuclear receptors that govern genes for mitochondrial biogenesis, oxidative phosphorylation, fatty acid oxidation and the Krebs cycle. Skeletal muscle cannot adapt to aerobic training without them, which makes an ERR agonist a natural candidate for an exercise mimetic.
As a pan-agonist, SLU-PP-332 switches on all three ERRs, and it is most potent at ERR alpha. The Burris group demonstrated that its effect on exercise capacity relied specifically on ERR alpha. That sets it apart from other exercise mimetic targets, such as AMPK, which AICAR activates and MOTS-c activates indirectly, and PPAR delta. MOTS-c is for sale in Australia in 10, 20 and 40 mg vials for AMPK comparison arms.
Shop SLU-PP-332 for Sale With the Mouse Study Findings in Hand
The efficacy evidence published so far rests on a handful of papers, all written by Burris and his collaborators and all conducted in cells or mice.
- ACS Chemical Biology (2023), Billon and co-authors. Working with a skeletal muscle cell line, the authors saw mitochondrial function and respiration improve. In mice it raised the proportion of type IIa oxidative muscle fibres, turned on an acute aerobic exercise gene programme that depends on ERR alpha, and lengthened treadmill running time and distance.
- Journal of Pharmacology and Experimental Therapeutics, volume 388 (2024, online 2023), Billon and co-authors. Using leptin-deficient ob/ob mice and diet-induced obese mice, the team found the compound raised energy expenditure and fatty acid oxidation, limited the build-up of fat mass and improved insulin sensitivity.
- Wang et al., American Journal of Pathology, 2023. ERR agonism undid mitochondrial dysfunction and inflammation in the kidneys of ageing mice.
Does SLU-PP-332 work, then? In mice, and on the endpoints those studies chose, it does. For now that is the limit of the evidence. Order the SLU-PP-332 vial online from our Australian stock to follow those mouse study designs.
Buy SLU-PP-332 Knowing There Are No Human Trials Yet
Not a single human study of SLU-PP-332 has been published, and at the time of writing ClinicalTrials.gov lists no registered trials. The University of Florida, where Burris now works, publicised the metabolic syndrome findings in 2023. It said the next steps were to refine the structure towards a drug candidate and carry out more animal testing, with no mention of human trials.
Since then the lab has taken a revealing turn. A 2026 paper in JPET presented SLU-PP-915, a chemically different ERR pan-agonist, and stated that SLU-PP-332 lacks oral bioavailability. In the mouse work SLU-PP-332 was delivered by intraperitoneal injection. This is important for anyone planning an oral-route study with the capsule format. The lab that created the molecule says oral exposure is poor, so exposure should be measured, never assumed.
Order SLU-PP-332 With the Known and Unknown Side Effects in View
Side effects draw more questions than almost anything else about SLU-PP-332, and the truthful answer is that its side effects in people are unknown. In the mouse metabolic study the researchers saw no severe side effects. Nobody has published a formal toxicology package, human pharmacokinetics or a long-term animal safety study.
The biology suggests a few open questions. Heart muscle, kidney and brown fat show high ERR activity, and these are all tissues with high energy demands, and the long-term effects of stimulating those receptors have not been reported. Because energy expenditure and fat oxidation rise, body temperature and food intake are also worth recording in any animal study design. In our view SLU-PP-332 is a useful tool compound for probing ERR biology and should be handled as exactly that, not as a ready-made "exercise pill".
Shop SLU-PP-332 Online in Australia for Lab Research
No approved medicine anywhere contains SLU-PP-332, and it does not appear on the ARTG. Anyone considering use beyond the lab should first consult the current Poisons Standard. NovaPep supplies it to adults 18+ and to laboratories for research purposes only. It is not for people or animals, and nothing on this page is dosing advice.
You can order it through our SLU-PP-332 research listing, where both formats appear on a single page, a 5 mg lyophilised vial and a 60-capsule pack of 250 mcg capsules. An independent laboratory tests each lot, and the lot number printed on the vial or pack links to its report on the COA lookup. Our quality testing page describes the methods used.
Not sure which to choose? Order the vial if your design follows the published mouse studies, and read our capsules versus vial comparison before going for the bottle. If you are after SLU-PP-332 near me, you will not find it on a local shelf, because we ship it online from Australian stock to laboratories across the country. Many teams also add MOTS-c or SS-31 for mitochondrial comparison arms that run beside the ERR agonist.
What Is SLU-PP-332? A Guide to the Exercise Mimetic Compound FAQ
Does SLU-PP-332 count as a peptide?
It does not. SLU-PP-332 is a small synthetic molecule (C18H14N2O2, molecular weight about 290) containing no amino acids, an acyl hydrazone that activates the estrogen-related receptors. Peptide suppliers stock it because it is studied alongside mitochondrial and metabolic peptides like MOTS-c.
What side effects does SLU-PP-332 have?
Its effects in people are unknown, since it has never been given to humans in a study. The mouse researchers saw nothing severe. There is still no formal toxicology work or long-term safety data in print, and nobody has looked at what years of exposure might mean for energy-hungry tissues like the heart and kidney.
Have any human studies of SLU-PP-332 been done?
None so far. Every published SLU-PP-332 result comes from cell and mouse work by Thomas Burris and his collaborators. At the time of writing ClinicalTrials.gov shows no registered human trials, and the lab's more recent work centres on a separate compound, SLU-PP-915.
Can SLU-PP-332 be absorbed orally?
Its developers say it cannot. A 2026 JPET paper from the Burris lab states that SLU-PP-332 lacks oral bioavailability, and the mouse studies delivered it by intraperitoneal injection. That paper also introduced SLU-PP-915 as an orally active alternative. Any oral-route research design should measure exposure instead of assuming it.
Is SLU-PP-332 available to buy online in Australia?
Yes, for laboratory research. NovaPep ships SLU-PP-332 from Australian stock as a 5 mg vial or a 60-capsule bottle, with an independent certificate for each lot. It is not an approved medicine and has no ARTG listing, so consult the current Poisons Standard first if any non-laboratory use is contemplated. None of our products are for human or veterinary use.