PT-141 10 mg lyophilised peptide vial with white cap and pink and blue label

NovaPep

Buy PT 141 Peptide Australia: PT-141 10mg Research Vial and Nasal Spray (Bremelanotide)

$59AUD, GST included

In stock in Australia, batch certificate ready

Certificate of analysis published for every batch
Third-party HPLC purity and MS identity testing
Dispatched same day before 3pm cut-off, tracked Australia-wide
Research use only, sold to adults aged 18 and over

Buy PT 141 peptide online in Australia as a 10 mg research vial or a 10 mL nasal spray, tested on every lot. The PT 141 peptide is bremelanotide, a ring-shaped heptapeptide (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) that activates the MC3 and MC4 melanocortin receptors in the brain. It differs from Melanotan 2 only by a free acid at the C-terminus, and it sits among our melanocortin peptides. Its identity markers are C50H68N14O10, a molar mass of 1025.2 g/mol and CAS 189691-06-3. Every lot is checked by HPLC for purity and by mass spectrometry for identity, and your lot's certificate opens ahead of checkout. Put bacteriostatic water in the same cart, because the vial is dry powder with no diluent, and then use the PT-141 calculator to turn a chosen water volume into a working strength. Groups running ligand comparisons frequently include Melanotan 2, the amidated parent compound. Keep the unopened PT-141 vial at -20 °C and out of light. Every unit is a research reagent, supplied solely to buyers aged 18 or older.

For laboratory research use only. Not for human or veterinary use. Not TGA approved. See the NovaPep research use policy.

What Is the PT 141 Peptide?

PT-141, called bremelanotide in clinical papers, is a small synthetic ring peptide that switches on melanocortin receptors in the brain, chiefly the MC4 receptor, a pathway linked to appetite and sexual motivation. It works on brain circuits and not on blood vessels, and that difference matters more than anything else about it. You can order PT-141 online in Australia as a 10 mg research vial or a 10 mL nasal spray, and every lot ships with its own certificate.

PT-141 grew out of research on Melanotan 2 during the 1990s. Replacing that cyclic peptide's C-terminal amide with a free carboxylic acid produced bremelanotide, which keeps the same ring but shifts the receptor balance. It is used when the question at the bench is focused, specifically what happens when MC3 and MC4 receptors, both plentiful in the brainstem and hypothalamus, are switched on with reduced pull on the MC1 pigment receptor.

The ring is closed by a lactam bridge linking aspartic acid and lysine, holding the His-D-Phe-Arg-Trp core that every melanocortin receptor recognises. Acetylation at the N-terminus and norleucine instead of methionine guard the chain against exopeptidases and oxidation. Of all the residues, tryptophan is the one most sensitive to light, which is why the powder should be kept dark.

How PT-141 Works in the Melanocortin System

A Short Guide to the Melanocortin System

Neurons in the arcuate nucleus of the hypothalamus produce a large precursor protein, POMC, and cleave it into smaller signals, including alpha-MSH. Alpha-MSH acts at five melanocortin receptors, MC1R through MC5R, each of which couples to Gs and raises cyclic AMP. MC1R is located on skin pigment cells. The brain holds most of the MC3R and MC4R, and MC4R in particular is found on paraventricular nucleus neurons that balance energy status against other drives. The system carries its own brake as well, agouti-related peptide, which a nearby group of neurons releases to block the same receptor. Human genetics underlines how important MC4R is, because defective copies of the MC4R gene are the most frequent monogenic cause of severe obesity beginning in early childhood.

This is what separates PT-141 from the vascular drugs it is often compared with. Phosphodiesterase 5 inhibitors work on smooth muscle in blood vessels and depend on a signal that has already started. The PT 141 peptide acts higher up, in the circuits that create the drive to begin with.

PT-141 Research: What Studies Have Looked At

Results From the Clinical Trials

Approval was based on RECONNECT, a pair of identical phase 3 trials reported in Obstetrics and Gynecology in 2019, led by Sheryl Kingsberg. Between them, 1,267 women who were premenopausal and had hypoactive sexual desire disorder were assigned at random to bremelanotide or placebo for 24 weeks. Questionnaire scores for desire and for associated distress served as the coprimary endpoints, and those findings underpinned US approval later in 2019. Nausea was the adverse event reported most often. Labs planning similar studies can order PT-141 online in Australia, with identity and purity confirmed on every lot.

In the lab, we suggest handling bremelanotide as a tool that leans toward MC4R rather than one that is purely selective. It also binds MC1R and MC3R, so assigning effects to a receptor requires either a cell line expressing just one subtype or a selective antagonist run alongside. If you want to compare it with its two Arizona relatives, our complete guide setting bremelanotide against both Melanotan peptides covers all three.

It suits cAMP and binding assays in cell lines carrying transfected receptors, mapping of melanocortin circuits in rodent tissue and cardiovascular readouts in animal models. A formulated bremelanotide product won approval in the United States in 2019 under the name Vyleesi. NovaPep neither sells nor represents that medicine, and every item on this page is a research reagent.

Bremelanotide Approval Abroad and Status in Australia

The compound was developed by Palatin Technologies, based in New Jersey, which used the name Rekynda for a while. Palatin granted AMAG Pharmaceuticals the North American rights in 2017, and the US FDA approved AMAG's application on 21 June 2019. Vyleesi, the approved product, is a prefilled autoinjector for a single narrow indication in premenopausal women and Cosette Pharmaceuticals now markets it in the United States.

Australia did not follow suit. When we searched the PI and CMI database run by the TGA during October 2026, it found nothing for bremelanotide or Vyleesi, and we could locate no ARTG registration, meaning no Australian pharmacy can dispense it on prescription. Its legal position is less clear-cut than that of its parent. Melanotan II is listed by the Poisons Standard (June 2026 instrument) in Schedule 4, yet the instrument has no entry under the name bremelanotide or PT-141, and we could find no published TGA scheduling decision on it. We treat that as an unresolved question rather than a green light, and the regulator's repeated alerts about melanotan products make clear that this receptor class is watched closely.

PT-141 Specifications and Formats

Product name	PT-141 (bremelanotide)
Formats	10 mg lyophilised vial, 10 mL nasal spray
Sequence	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, cyclised through a lactam bridge
Chain length	7 amino acids
Formula	C50H68N14O10
Molecular weight	1025.2 g/mol
CAS	189691-06-3
Appearance	Freeze-dried powder sealed in a glass vial, or peptide pre-dissolved in a pump bottle for the spray
Quality checks	HPLC for purity and mass spectrometry for identity, with a certificate issued for each lot
In the box	Either a single vial with 10 mg of PT-141 powder and no diluent (bacteriostatic water purchased separately) or a single ready-to-use 10 mL spray bottle
Storage conditions	Unopened vial kept dry and dark at -20 °C. Spray and any reconstituted solution kept at 2 to 8 °C
Stock status	In stock
Intended use	In vitro laboratory research only

This listing includes two physical products. The glass vial has a white cap and a pink and blue label and contains 10 mg of bremelanotide in lyophilised white powder form. The spray comes as ready-dissolved solution in a 10 mL bottle topped with a silver collar and white pump actuator.

PT-141 suits studies that call for a melanocortin ligand weighted toward the central receptors instead of the wide profile of Melanotan 2. Each format is in stock, every lot leaves with its own HPLC report, and our melanocortin range shows related compounds worth comparing before checkout.

One molecule comes in two formats. The 10 mg vial leaves the concentration up to you, which suits receptor assays and any method that calls for an unusual strength. The nasal spray holds 10 mL already dissolved at a strength fixed at the factory, which makes it a fit for formulation comparisons and for any protocol specifying a bottled liquid. Most labs go with the vial, since the spray costs a little more for convenience, not more peptide.

Confirming PT-141 by Mass

Only about one mass unit separates bremelanotide from Melanotan 2 (1025.2 against 1024.2 g/mol), which means a measured mass is the only way to know which is in the vial. Confirm that the mass spectrometry value on the certificate agrees with 1025.2 g/mol and note the HPLC purity for that lot. Look up the report by its lot number in the COA library, and our article on how to read a COA explains every line.

Handling and Storage of PT-141

For reconstitution, bring the vial to room temperature, trickle the diluent along the vial wall and give it a gentle swirl until the liquid is clear, without ever shaking. As an example, adding 2 mL of bacteriostatic water to the 10 mg vial produces 5 mg per mL. Other volumes are handled by the PT-141 reconstitution calculator, and our reconstitution guide describes the aseptic technique. Order PT-141 online in Australia and it travels by tracked Australia Post from our local stock.

Unopened, the powder stays at -20 °C in the dark. Once dissolved it goes into the fridge at 2 to 8 °C, preferably in aliquots so the stock is not repeatedly warmed and chilled. Never freeze the spray. Keep it refrigerated and use it up by the date on its label.

PT-141 Compared With Melanotan 2

The research question should guide the choice. Melanotan 2 broadly activates MC1R, MC3R, MC4R and MC5R, so it makes a convenient positive control and the standard option for pigmentation studies, and it is supplied as a 10 mg vial. PT-141 is the better fit when a project focuses on MC3R and MC4R and wants less MC1R activity in the background.

Neither compound is perfectly selective, so teams teasing apart MC4R and MC3R effects include receptor antagonists in their design. Running both gives a neat structural pair sharing the same ring with a single changed terminus. For upstream signalling on the reproductive axis, kisspeptin is the related reagent labs most often add.

Other Names for PT-141

You will find this compound called PT-141, PT 141, PT141 or bremelanotide, and earlier papers describe it as a deamidated derivative of Melanotan 2. All of these refer to one heptapeptide, CAS 189691-06-3, formula C50H68N14O10.

Knowing the receptor terms helps too. MC1R is the receptor on melanocytes, the melanocortin 3 and 4 receptors are abbreviated MC3R and MC4R, and every member of the family responds to the natural ligand alpha-MSH (alpha-melanocyte-stimulating hormone). Research papers generally describe PT-141 as a melanocortin agonist whose activity favours MC3R and MC4R.

Buy PT 141 Peptide Online in Australia

So why do research suppliers stock it? Bremelanotide is a thoroughly studied ligand of MC3R and MC4R backed by published clinical data, and since no product is registered here, a research supplier is the only way an Australian lab can buy PT-141 in a weighed amount. NovaPep keeps PT 141 for sale in Australia in each format, purely as laboratory reagents. Every buyer has to be at least 18, and the spray and vial alike are unsuitable for people or animals. Our comparison of Melanotan 1, Melanotan II and PT-141 lines up all three melanocortin peptides.

Labs comparing the best PT 141 peptide sources should check that the lot certificate names bremelanotide and matches the vial in hand.

Order all the vials a lengthy series will need together so that, where stock allows, they ship from one lot under one certificate. That way the analytical record stays the same from the first experiment to the final one. Each buyer confirms an age of 18 or more during checkout, and no order is accepted without that confirmation.

NovaPep has no shopfront or collection counter. Order online and your parcel travels from Australian stock to any state or territory, so a lab ordering peptides in Perth, Hobart or Cairns gets the same lot-tracked stock as a lab in Sydney. When payment clears before 3pm on a business day, the parcel leaves that afternoon, and transit times are listed on the delivery information page.

More on Buying PT-141 in Australia

Is PT-141 a treatment for erectile dysfunction?

No, and NovaPep makes no therapeutic claims. Searches for the best peptide for erectile dysfunction, PT-141 included, often confuse research reagents with medicines. Bremelanotide was approved overseas as Vyleesi for low sexual desire in premenopausal women, not for erectile dysfunction. Our vial and spray are for in vitro melanocortin research only.

PT-141 at a Glance

Ring-shaped melanocortin agonist

PT-141, or bremelanotide, is a seven-residue cyclic peptide whose only difference from Melanotan 2 lies at the C-terminus. That small edit pushes its activity toward MC3R and MC4R.

Order powder or spray

The vial is dry powder without diluent, so include bacteriostatic water. The spray comes already in solution.

Used in receptor and circuit research

Researchers use it for melanocortin signalling and binding work in cultured cells and map central pathways in rodent tissue, in the lab only.

Compared with Melanotan 2

Melanotan 2 covers MC1R through MC5R broadly and suits pigmentation studies. PT-141 is preferred when MC3R and MC4R are the target.

Powder frozen, solution chilled

Store the sealed vial at -20 °C out of light. Keep reconstituted solution and the spray bottle at 2 to 8 °C.

Tested lot by lot

Every lot is checked by mass spectrometry for the 1025.2 g/mol mass and by HPLC for purity, and the certificate is available before purchase.

PT-141 (Bremelanotide) FAQ

What is PT-141 and how does it work?

PT-141 is bremelanotide, a cyclic seven residue melanocortin agonist derived from Melanotan 2 by swapping the C-terminal amide for a free acid. It activates MC3R and MC4R in the brain, raising cAMP, and acts on central circuits rather than on blood vessels.

Is there a place to get PT 141 peptide near me?

Yes, order it online from NovaPep. Choose the 10 mg vial or the 10 mL spray, and paying before 3pm on a weekday means same-day dispatch from local stock to all Australian states and territories. With no shopfront or pickup point, every lab is sent identical lots, and you can follow the parcel on the track order page.

Is a certificate of analysis supplied with PT-141?

Yes, every PT-141 lot has its own certificate. Mass spectrometry confirms identity, which is important because PT-141 and Melanotan 2 are only about one mass unit apart, and HPLC measures purity. Find the report in the COA library with the lot number printed on your vial or spray label.

Which should I buy, PT-141 or Melanotan 2?

Buy PT-141 for studies built around the central MC3 and MC4 receptors, and Melanotan 2 when you want broad activation across MC1R to MC5R, pigment research included. Because they share a cyclic core and vary only at the C-terminus, ordering both gives a neat structural comparison in a single delivery.

Which PT-141 format suits my lab better, vial or spray?

Go with the 10 mg vial if you want control over concentration and long-term frozen storage. Pick the spray when your protocol needs a prepared solution and work will begin shortly, since a liquid is refrigerated instead of frozen and has a shorter usable window.

How do laboratories use PT-141?

Researchers use it in vitro as a reference melanocortin agonist to investigate MC3R and MC4R signalling, for instance in cAMP and receptor binding assays on transfected cells. NovaPep sells it purely as a research reagent and only to buyers 18 or older. It is not a medicine, and no sale is made for human or veterinary use.