Kisspeptin 5 mg lyophilised peptide vial with orange flip-off cap and white label

NovaPep

Buy Kisspeptin Australia: Kisspeptin 5mg and 10mg Research Vials

$45AUD, GST included

In stock in Australia, batch certificate ready

Certificate of analysis published for every batch
Third-party HPLC purity and MS identity testing
Dispatched same day before 3pm cut-off, tracked Australia-wide
Research use only, sold to adults aged 18 and over

Buy kisspeptin online in Australia in 5 mg and 10 mg research vials of kisspeptin-10, tested on every lot. Kisspeptin-10 is the shortest product of the KISS1 gene that still binds the KISS1 receptor, also called GPR54, with full affinity. Because that receptor acts upstream of gonadotropin-releasing hormone, the peptide is a routine tool in reproductive axis studies. Identity details are published openly, with the one-letter sequence YNWNSFGLRF-NH2, formula C63H83N17O14, molar mass 1302.4 g/mol and CAS 374675-21-5. Mass spectrometry confirms every lot and HPLC records its purity, and the certificate can be opened ahead of checkout. Use the peptide calculator to turn any diluent volume into a concentration. For a second hypothalamic neuropeptide, add oxytocin to the same order. The vial contains powder only, so include bacteriostatic water, and keep it sealed at -20 °C out of the light. Kisspeptin is a research reagent supplied only to adults aged 18 and over.

For laboratory research use only. Not for human or veterinary use. Not TGA approved. See the NovaPep research use policy.

What Is Kisspeptin?

Kisspeptin is a naturally occurring brain peptide that works as the main on switch for the reproductive hormone system, signalling to GnRH-producing neurons when they should fire. If the kisspeptin signal fails, puberty never begins. The vial we sell holds kisspeptin-10, a short synthetic version that carries the complete signalling end of the natural hormone. Kisspeptin is for sale in Australia as a 5 mg or 10 mg research vial, ready to order online from local stock.

The kisspeptins form a family of fragments cleaved from the KISS1 precursor, measuring 54, 14, 13 and 10 residues. In 1996 researchers in Hershey, Pennsylvania found the gene during a hunt for suppressors of cancer spread, which explains why kisspeptin-54 was originally called metastin. All forms share the same last ten residues, and that segment is responsible for receptor binding. Two groups tied receptor mutations in GPR54 to a lack of puberty in 2003, and kisspeptin gained its reputation as a gatekeeper of the reproductive axis.

We supply kisspeptin-10, the shortest form that keeps full receptor activity and the version most commonly used in the lab. In the pathway studied, kisspeptin binds KISS1R on hypothalamic GnRH neurons, GnRH is released, and the pituitary responds by releasing follicle-stimulating hormone and luteinising hormone. Labs use it to investigate that chain in cells, tissues and animal models. It is a reagent for research rather than a medicine, listed in our melanocortin and reproductive research peptides range and in our nootropic research peptides.

Where the name comes from

The unusual name has a simple explanation. Its discoverers found the gene in Hershey, Pennsylvania, and named it after the chocolate kiss, the town's most famous product. Only later did it become clear that the peptide matters more for reproduction than for the cancer spread it was originally studied in.

Inside the kisspeptin-10 decapeptide

The most important feature is the C-terminal Arg-Phe-NH2. The amide is essential for receptor binding, and it places kisspeptin in the RF-amide peptide family. If a batch lost that amide it would end in a free acid and read roughly 1 dalton heavier, a small but revealing change. The tyrosine and tryptophan residues absorb UV strongly and are also the parts of the chain most likely to oxidise.

How Kisspeptin Switches On the Reproductive Axis

KISS1R, the receptor, is coupled to Gq. Once bound, it switches on phospholipase C, calcium levels climb, and the GnRH neurons depolarise and fire, releasing a pulse of GnRH into the portal blood that carries it to the pituitary. Two clusters of kisspeptin cells in the hypothalamus control this process. The arcuate nucleus houses the KNDy neurons, which release kisspeptin together with neurokinin B and dynorphin. Neurokinin B quickens the rhythm and dynorphin slows it, and this tug of war is now seen as the engine of the GnRH pulse. In rodents, a separate population close to the third ventricle drives the big hormone surge that comes before ovulation.

Kisspeptin Research: What Studies Have Looked At

Human physiology studies have been unusually clear. George and colleagues reported in 2011 that kisspeptin-10 strongly stimulated luteinising hormone in healthy men, and that a constant infusion raised LH pulse frequency from roughly 0.7 to 1.0 pulses per hour. At the higher infusion rates, separate pulses could no longer be told apart. Shop Kisspeptin online in Australia for this research, knowing each lot has been checked for identity and purity.

That detail flags the mistake we see most. Kisspeptin is most effective when delivered in pulses, and constant exposure may shut the system down instead of switching it on. Seminara's group showed this in young male rhesus monkeys, where a continuous infusion of the decapeptide stimulated the axis at first before the receptor desensitised and the LH response dropped away. A slice or culture experiment that soaks cells in kisspeptin for hours may therefore end up studying tachyphylaxis by accident. We advise settling early on whether the question is about acute activation or sustained exposure, then building in washouts or intermittent pulses to suit. Labs comparing the kisspeptin peptide with other neuroendocrine tools can look at our oxytocin peptide for research, which covers a different hypothalamic receptor system.

Most peptides on our site began as synthetic drug candidates, but kisspeptin is a fragment of a natural human hormone, and within ten years of its gene being found it had moved from cancer biology into endocrinology. Clinical teams in the United Kingdom and other countries have since given kisspeptin to volunteers in fertility trials and physiology studies, but no regulator has approved a kisspeptin medicine and nothing containing it is registered in Australia.

Kisspeptin-10 Specifications

Product name	Kisspeptin-10 (KP-10)
Sizes	5 mg vial, 10 mg vial
Sequence	YNWNSFGLRF-NH2 (tyrosine 1 to phenylalanine 10), amidated C-terminus
Residues	10 amino acids
Formula	C63H83N17O14
Molecular weight	1302.4 g/mol
CAS	374675-21-5
Presentation	Freeze-dried powder in a sealed glass vial under an orange flip-off cap
Quality checks	Identity by mass spectrometry and purity by HPLC, with each lot certificate online before sale
In the box	A single kisspeptin-10 vial (5 mg or 10 mg), no diluent included, bacteriostatic water sold separately
Storage conditions	Unopened vial dry and dark at -20 °C. Once reconstituted, 2 to 8 °C
Stock status	In stock
Intended purpose	Laboratory in vitro research only

Two fills are offered for KISS1R signalling studies. The 5 mg vial suits pilot curves and method development, and the 10 mg vial suits regular use at a lower price per milligram. Both sit in Australian stock, and every lot has its own certificate.

Keep the certificate open while you order and check for a measured mass matching 1302.4 g/mol, a single main HPLC peak and a purity value linked to your lot. All certificates sit in the certificate of analysis library by lot number, and our guide to reading a COA walks through each result. The mass data also distinguishes kisspeptin-10 from longer versions like kisspeptin-13 or kisspeptin-14, which have extra N-terminal residues and are noticeably heavier.

Handling and Storage of Kisspeptin

Bring the vial to room temperature before you open it, run the diluent slowly down the glass, and then turn the vial so the liquid washes the walls and picks up all the powder. Putting 2.5 mL of bacteriostatic water for peptides into the 10 mg vial gives 4 mg/mL, about 3.1 mM at 1302.4 g/mol, and the reconstitution calculator works out other volumes. Kisspeptin for sale in Australia leaves our shelves by tracked post, so it reaches your bench in good condition.

Keep the unopened vial at -20 °C shielded from light and moisture to protect the tyrosine and tryptophan. Once mixed, hold the solution at 2 to 8 °C in aliquots that are each thawed only once.

Kisspeptin Compared With Oxytocin

Each is a hypothalamic neuropeptide, but they act at different stages. Kisspeptin operates upstream of GnRH, so it suits research into the reproductive axis, puberty timing models and pulsatile hormone release. Our oxytocin, a cyclic nonapeptide that acts at OXTR, fits smooth muscle preparations, stress-axis studies and social behaviour work. Use kisspeptin when the readout is GnRH or LH, oxytocin when it is OXTR signalling, and both if a study spans the two systems. Each peptide has an amidated C-terminus, so the same attention to storage and mass checks applies to both.

Groups studying central melanocortin signalling sometimes include PT-141, which works through a different receptor family.

Other Names for Kisspeptin

You may see kisspeptin-10 listed as KP-10, Kp-10 or metastin 45-54, or written by its one-letter code YNWNSFGLRF-NH2. Its longer relatives are kisspeptin-13, kisspeptin-14 and kisspeptin-54, the last of which used to be called metastin. Older papers refer to the receptor as AXOR12, GPR54 or KISS1R, and the hypothalamic neurons that make kisspeptin are commonly known as KNDy neurons. What we sell is the decapeptide, CAS 374675-21-5, which some kisspeptin peptide catalogues also describe as the human metastin fragment.

Buy Kisspeptin Online in Australia, Vial Sizes and Legal Status

Lift the orange flip-off cap and you will find kisspeptin-10 only, a small white plug of lyophilised powder in the 5 mg or 10 mg fill, without any of the longer kisspeptin forms mixed through.

Choose the 5 mg vial for an initial concentration-response curve in cells expressing KISS1R, a brief pilot or any project that might be paused. The 10 mg vial brings the cost per milligram down and fits established protocols using material at a steady rate. Kisspeptin-10 works at nanomolar concentrations in cell assays, so either size lasts through a long series. Pulse designs that repeat short exposures consume more peptide over time and usually point to the bigger vial.

Order several vials together so a study stays on one lot and one certificate where stock permits, taking a batch change off your list of variables. We sell kisspeptin only to adults aged 18 and over.

The legal position is therefore unusual. As of October 2026, the Poisons Standard (June 2026 instrument) does not name kisspeptin at all, in contrast to the growth hormone peptides we carry, and the TGA product information database lists nothing under that name. A general Schedule 4 entry for hypothalamic releasing factors does exist in the standard, and whether it captures a peptide acting above GnRH is for the TGA to decide, not a supplier, so we do not claim kisspeptin is unscheduled. In practice research suppliers are the source of kisspeptin Australia labs can actually get, because there is no pharmaceutical form.

The sporting position is more straightforward. Kisspeptin acts upstream of LH in the reproductive cascade, so WADA's 2026 Prohibited List bans kisspeptin and its agonist analogues for male athletes in class S2.1, together with GnRH agonists and chorionic gonadotrophin, and Sport Integrity Australia enforces that rule.

To buy kisspeptin peptide in Australia for reproductive axis or receptor studies, both vial sizes can be ordered now from local stock. They are supplied to adults 18 or older as experimental reagents and are not for administration to humans or animals. A related hypothalamic option is our oxytocin 10 mg vial, which works through its own receptor, OXTR, not KISS1R.

Few local outlets carry kisspeptin, and NovaPep does not have a shopfront. We sell online only and post to every address in Australia from local stock, with orders paid before 3pm on a business day leaving the same afternoon, as set out on our shipping information page. Labs buying peptides on the Gold Coast get the same certified lots as everyone else.

Kisspeptin at a Glance

The active tail of KISS1

Kisspeptin-10 is the ten-residue C-terminal piece that every kisspeptin shares, and it binds GPR54, the KISS1 receptor.

Buy 5 mg or 10 mg Online

Sealed lyophilised vials come in 5 mg or 10 mg. Diluent is sold separately, so add bacteriostatic water.

Research on the reproductive axis

Labs use it to examine GnRH, LH and FSH release in cell, tissue and animal models of reproduction, and supply is restricted to lab work.

Above the oxytocin pathways

Oxytocin works through its own receptor, OXTR. Kisspeptin is the pick when the question lies upstream of GnRH.

Cold and dark storage

Keep closed vials at -20 °C away from light to protect tyrosine and tryptophan. Hold solutions at 2 to 8 °C in aliquots thawed once.

Amide and mass confirmed

Mass spectrometry checks the amidated sequence and HPLC measures purity, with a certificate published for each lot.

Kisspeptin FAQ

What is kisspeptin and how does it work?

Kisspeptin is a natural hypothalamic peptide cut from the KISS1 precursor. It binds KISS1R, a Gq coupled receptor on GnRH neurons, which raises calcium and makes those neurons fire. The GnRH pulse then drives pituitary release of luteinising hormone and follicle-stimulating hormone.

Do you sell kisspeptin-10 or kisspeptin-54?

We sell kisspeptin-10, the C-terminal decapeptide YNWNSFGLRF-NH2, which is the shortest form with complete receptor activity and the one most researchers use. Kisspeptin-54 is longer and lasts longer in circulation in animal work, but we do not stock it, so the certificate always shows the decapeptide mass.

What do laboratories use kisspeptin for?

Kisspeptin-10 is a reference KISS1R agonist used to examine how the hypothalamus drives the reproductive hormone cascade. Researchers apply it to tissue preparations, cell lines and animal models. It is supplied for in vitro lab research only and is not for human or veterinary use.

Should I buy kisspeptin or oxytocin?

Buy kisspeptin if your study is about the reproductive axis above GnRH, for example puberty models or LH release. Buy oxytocin for OXTR signalling in smooth muscle, stress or social behaviour preparations. Both are research reagents and can be shipped together in one order.

Is a certificate of analysis supplied with kisspeptin?

Yes. Each kisspeptin-10 lot is tested by HPLC for purity and by mass spectrometry, which confirms the amidated sequence at 1302.4 g/mol. The certificate is published in the COA library, and the lot number printed on your vial leads you to the correct report.

How can I order kisspeptin online in Australia?

Select the 5 mg vial or the 10 mg vial here, put it in the cart and check out. We ship from Australian stock, and payment received before 3pm on a business day gets your order out that afternoon. The powder arrives dry, so add bacteriostatic water if you need diluent.