Semax 10 mg lyophilised peptide vial with teal flip-off cap and white label

NovaPep

Buy Semax Peptide Australia: Semax 10mg Research Vial and Nasal Spray

$59AUD, GST included

In stock in Australia, batch certificate ready

Certificate of analysis published for every batch
Third-party HPLC purity and MS identity testing
Dispatched same day before 3pm cut-off, tracked Australia-wide
Research use only, sold to adults aged 18 and over

Buy Semax peptide online in Australia as a 10 mg research vial or a 10 mL nasal spray, tested on every lot. Semax peptide is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro, made by attaching a Pro-Gly-Pro tail to the ACTH 4 to 7 fragment at the Institute of Molecular Genetics in Moscow. It has no corticotropic activity, and research groups mostly use it to examine BDNF and TrkB expression in rat brain and in cerebral ischaemia models. Its identity markers are C37H51N9O10S, 813.9 g/mol and CAS 80714-61-0. Mass spectrometry and HPLC are run on every vial and spray lot, and the certificate is available to read before payment. We hold it locally as a 10 mg lyophilised vial or a ready-to-use 10 mL nasal spray at 1 mg/mL. Use the peptide calculator to set a custom strength from the vial, and add bacteriostatic water because the powder ships dry. Selank is the natural partner for a two-peptide comparison. Keep the unopened vial frozen at -20 °C until needed. Semax is sold as a research reagent to customers 18 years and older.

For laboratory research use only. Not for human or veterinary use. Not TGA approved. See the NovaPep research use policy.

What Is Semax Peptide?

Semax is a short synthetic peptide derived from part of ACTH, the stress hormone, retaining its influence on brain signalling while dropping the hormone's effect on the adrenal glands. Labs use it chiefly to investigate how neurons control BDNF, a growth factor that helps nerve cells survive and synapses strengthen. You can order Semax online in Australia as a 10 mg research vial or a 10 mL nasal spray, and every lot ships with its own certificate.

Semax was designed at the Institute of Molecular Genetics in Moscow, part of the Russian Academy of Sciences. Its leading sequence, Met-Glu-His-Phe, reproduces positions 4 to 7 of adrenocorticotropic hormone, a section associated with neurotrophic activity rather than adrenal effects. Thanks to the Pro-Gly-Pro tail, peptidases degrade it more slowly, so the seven-residue chain outlasts the native fragment.

How a Pituitary Hormone Became a Brain Peptide

Released by the pituitary, ACTH is a 39-residue hormone that instructs the adrenal cortex to produce cortisol. During the 1960s and 1970s, David de Wied and his team in Utrecht found that short ACTH fragments, particularly the 4 to 10 region, altered learning and avoidance behaviour in rats without causing any steroid release. Those findings helped shape the concept of neuropeptides, hormone fragments that act on the brain independently. Researchers in Moscow led by Nikolai Myasoedov and Igor Ashmarin then took the shorter 4 to 7 section and added a proline-rich tail to help it persist in tissue.

How Semax Works in the Brain

Semax keeps the part of ACTH linked to brain signalling and drops the part that drives the adrenal glands. In practice it does not trigger cortisol release, so any effect seen in a model is not a steroid effect. Its best studied action is on neurotrophin signalling, where it raises BDNF and the TrkB receptor that BDNF binds.

Here is a useful detail. The classic binding core for melanocortin receptors is His-Phe-Arg-Trp, at positions 6 to 9 of ACTH, and Semax retains only the His-Phe half. That partly explains why simple melanocortin receptor agonism does not account for its activity and why researchers still argue over its mechanism.

The proline-rich tail matters for how it behaves in tissue. Peptidases break down the native ACTH 4 to 7 fragment quickly, and the Pro-Gly-Pro extension slows that degradation so the peptide persists long enough to study.

Semax Research: What Studies Have Looked At

Most research groups use Semax to measure brain-derived neurotrophic factor and its TrkB receptor in rat hippocampus and cortex. Others apply it in middle cerebral artery occlusion models to track genes linked to inflammation and the growth of new vessels, and transcriptomic studies plus work on dopamine and serotonin systems complete the picture. It helps answer how a hormone fragment lacking hormonal activity can change neurotrophin expression. Find it in our nootropic peptides range, where it appears as a research reagent, not a medicine. Labs planning similar studies can order Semax online in Australia, with identity and purity confirmed on every lot.

Findings From the BDNF Research

The paper cited most often is a 2006 Brain Research study from Dolotov and co-workers. Following one intranasal dose of 50 µg/kg, rats showed hippocampal changes whose peak size varied with the marker measured.

exon III BDNF mRNA rose roughly 3-fold
TrkB receptor mRNA rose roughly 2-fold
TrkB tyrosine phosphorylation rose 1.6-fold
BDNF protein rose by 1.4-fold at most

In a learning task, the treated rats also gave more conditioned avoidance responses, linking the molecular shift to behaviour within one experiment.

Those numbers hold our key practical advice. The transcript effect is about double the protein effect, and it was measured for a single BDNF transcript. Because the BDNF gene has multiple promoters, each yielding a different first exon, primers that capture total BDNF mRNA can wash an exon-specific change out into background noise. For qPCR work with Semax, design exon-specific primers as well as a total BDNF assay, and back up the result with a protein measurement before deciding whether it is positive or negative.

Its History as a Medicine in Russia

Semax was first described in the scientific literature in 1991, and, unusually for a research peptide, it later became a prescription medicine in Russia. The Russian government also placed it on the List of Vital and Essential Drugs approved in late 2011. Beyond Russia and a handful of nearby markets, including in the United States, it has never been assessed or approved as a medicine. Independent randomised trials in Western countries have yet to be done.

Semax Specifications

Product	Semax
Sizes	10 mg vial, 10 mL nasal spray holding 10 mg
Structure or sequence	Met-Glu-His-Phe-Pro-Gly-Pro, the ACTH 4 to 7 fragment followed by Pro-Gly-Pro
Chain length	7 amino acids
Formula	C37H51N9O10S
Molar mass	813.9 g/mol
CAS	80714-61-0
Format	Vial contains lyophilised powder beneath a flip-off cap. Spray contains a 1 mg/mL solution in a 10 mL pump bottle
Analysis	Mass spectrometry for identity and HPLC for purity on each vial and spray lot, every one with its own certificate
In the box	Either a 10 mg vial without diluent (bacteriostatic water sold separately) or a spray bottle with 10 mg in 10 mL
Storage	Unopened vial at -20 °C, shielded from light and air. Spray and reconstituted vial at 2 to 8 °C
Stock	In stock
Intended use	Laboratory in vitro research only

The table covers both formats. The powder gives complete control over concentration, while the spray matches the intranasal methods that dominate Semax research. Each format contains 10 mg and has a certificate for its lot.

Inside the Semax Molecule

Pay attention to the methionine at position 1. Exposure to air and light can oxidise it, and on a certificate this appears as a secondary peak 16 daltons above the parent mass. Histidine and phenylalanine lend the chain aromatic character, which gives clean UV detection on HPLC.

A reliable certificate reports a measured mass consistent with 813.9 g/mol, a single main HPLC peak and a purity figure linked to the lot on your label. Every Semax certificate, for both powder and spray, is stored in the COA library.

Handling and Storage of Semax

To keep the methionine intact, leave the vial sealed in the freezer until the day it is required. Allow it to warm to room temperature, then slowly add fresh bacteriostatic water down the side of the glass. Putting 4 mL into the 10 mg vial makes 2.5 mg/mL, a convenient stock for further dilution, and the peptide calculator handles any other volume. Order Semax online in Australia and it travels by tracked Australia Post from our local stock.

Store the unopened vial at -20 °C away from light. After mixing, keep it at 2 to 8 °C in tightly capped aliquots with minimal headspace. Put the spray bottle in the fridge as soon as it arrives too.

Semax Compared With Selank

Choose Semax for research on neurotrophins, ischaemia models or dopamine and serotonin systems, where most of its published work lies. Pick Selank when your interest is GABA-related gene expression, enkephalin metabolism or cytokines. Both are seven residues long with a Pro-Gly-Pro tail, so any difference in response comes down to the head sequence, which is ACTH-derived in Semax and tuftsin-derived in Selank.

If your design involves sleep, DSIP is the third peptide available in the same spray format, so all three can be ordered together and handled with one routine.

Other Names for Semax

In one-letter code Semax is MEHFPGP, and written out in full it is Met-Glu-His-Phe-Pro-Gly-Pro. Russian publications frequently call it an ACTH 4 to 7 fragment extended by Pro-Gly-Pro, or an ACTH 4 to 10 analogue, since that longer fragment served as its model. Terms that commonly appear with it include BDNF, TrkB and melanocortin peptides. Under every one of these names it is the same 813.9 g/mol heptapeptide listed under CAS 80714-61-0.

Buy Semax Peptide Online in Australia

The vial contains a 10 mg plug of white freeze-dried Semax beneath a teal flip-off cap. The spray is a pump bottle filled to 10 mL with the same 10 mg already in solution.

The 10 mg vial is the one to choose when you need to dissolve powder at the precise strength your method requires, ideal for dilution series and cell experiments. The 10 mL nasal spray contains the same 10 mg pre-dissolved at 1 mg/mL behind a pump actuator. It costs a little more per milligram because you pay for the preparation and bottle, not more peptide. The spray saves time at the bench, but its concentration cannot be changed.

Order all the units for a study together and, where stock allows, they come from one lot with a single certificate, which keeps your records tidy when replicates are compared later. For intranasal panels, the Spray Research Kit bundles the Semax, Selank and DSIP sprays. The best Semax peptide for a lab is defined not by a label claim but by a matching lot number, a published certificate and cold storage from the moment the parcel arrives. Only adults 18 and over may buy Semax.

There is no shop where Semax can be collected. NovaPep trades only through this website, with no premises open to visitors, and delivers Australia-wide from local stock. Orders placed before 3pm on a business day are dispatched that day, and the delivery page sets out tracking and timeframes. Labs ordering research peptides in Canberra receive goods from the same stock.

How Australian Regulations Treat Semax

Is Semax legal in Australia? It is not named in the Poisons Standard as of October 2026. We checked the October 2026 instrument and found no Semax entry, so it has no schedule of its own. Registration in Russia gives it no status in Australia. Supplying a medicine here for therapeutic use requires inclusion on the Australian Register of Therapeutic Goods, and the TGA has named unapproved peptide products as a compliance priority. As a result, Semax in Australia is supplied by research reagent companies rather than pharmacies.

NovaPep stocks the vial and the Semax nasal spray locally, so Australian labs can order Semax as a research reagent for laboratory work. Orders are limited to adults 18 and over, and the peptide is not for human or veterinary use of any kind. Our peptide reconstitution guide explains how to prepare the powder, and the tuftsin-based Selank vial and spray carry the same Pro-Gly-Pro tail for side by side work.

Semax at a Glance

ACTH Fragment With No Hormonal Effect

Semax links ACTH 4 to 7 with a Pro-Gly-Pro tail, producing a seven-residue peptide that lacks corticotropic activity.

Acts on BDNF and TrkB

Its best studied action is raising BDNF and TrkB expression in rat hippocampus, while its exact receptor target is still debated.

Research on BDNF and Ischaemia

Applied to measuring BDNF and TrkB expression in rat brain and in cerebral ischaemia models, and sold purely as a laboratory reagent.

Compared With Selank

Selank has the same length and tail but is built on tuftsin, making it better suited to GABA and cytokine research.

Protect the Methionine

Leave the vial sealed and frozen until needed, reconstitute with fresh diluent, then refrigerate small tightly capped aliquots.

Buy the Vial or Spray online

The 10 mg vial holds dry powder and requires bacteriostatic water. The 10 mL spray contains the same 10 mg already in solution, and every lot has a certificate.

Semax FAQ

What is Semax peptide?

Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro, built from the ACTH 4 to 7 fragment plus a Pro-Gly-Pro tail. It was developed at the Institute of Molecular Genetics in Moscow. It keeps brain signalling activity from ACTH but has no corticotropic effect on the adrenal glands.

How does Semax work in research models?

Its best documented action is on neurotrophin signalling. In rat hippocampus it raised BDNF and TrkB mRNA and TrkB phosphorylation. It keeps only the His-Phe half of the melanocortin binding core, so simple melanocortin receptor agonism does not explain its activity, and the mechanism is still debated.

How is Semax used in laboratory research?

As a synthetic ACTH 4 to 7 analogue, Semax is used to investigate neurotrophin expression, responses to cerebral ischaemia and monoamine systems in rodent and cell models. It is supplied only as a research reagent for in vitro laboratory work and is never provided for human or veterinary use.

Is Semax or Selank the right one to buy?

Buy Semax for BDNF, TrkB and cerebral ischaemia models and Selank for GABA, enkephalin and cytokine studies. As both are heptapeptides ending in Pro-Gly-Pro, ordering one of each lets a single study isolate what the head sequence does. Both come as a 10 mg vial or a 10 mL spray.

Does the Semax nasal spray contain the same compound as the vial?

Yes. The spray contains the identical Semax heptapeptide, 10 mg in 10 mL at 1 mg/mL, and the vial contains 10 mg of dry powder. Order the vial if you want to choose your own concentration, and the spray when an intranasal design needs a solution with no reconstitution required.

What are the steps to order Semax online in Australia?

Put the 10 mg vial or the 10 mL nasal spray in your cart on this page and complete checkout. We hold stock in Australia, and orders paid for before 3pm on a business day ship that same day. Because the vial needs a diluent, add bacteriostatic water unless your lab already has some.