CJC-1295 DAC vs No DAC: Comparing the Two Versions for Research
The backbone of CJC-1295 with DAC and CJC-1295 without DAC is the same GHRH-derived chain, yet a single added chemical group transforms how each one behaves. The DAC form attaches to albumin in the bloodstream and remains active for about 6 to 8 days. That one distinction determines which version suits a particular study design, and mixing the two up is the ordering error we see more than any other.
Buy CJC-1295 Australia, DAC and No DAC Compared
| CJC-1295 with DAC | CJC-1295 no DAC (Mod GRF 1-29) | |
|---|---|---|
| Chain length | 30 residues, being Mod GRF (1-29) with an extra C-terminal lysine that holds the DAC group | 29 residues |
| Binds albumin | Yes, covalently, via the maleimide-based drug affinity complex | No |
| Half-life reported | About 6 to 8 days in human pharmacokinetic studies | About 30 minutes |
| Influence on GH pattern | Lifts trough (baseline) GH for several days while pulses carry on | A brief burst that follows the natural pulse |
| Usual study design | Infrequent administration with sustained elevation | Timed sampling of pulsatile release |
| Approximate molecular weight | About 3,647 g/mol | About 3,368 g/mol |
| NovaPep vial | CJC-1295 with DAC, 5 mg | CJC-1295 no DAC, 10 mg |
Shop CJC-1295 With DAC, What the Drug Affinity Complex Does
Natural growth hormone releasing hormone survives only minutes before dipeptidyl peptidase-4 cuts off its first two residues. Mod GRF (1-29) solves this through four amino acid swaps, at positions 2, 8, 15 and 27, which greatly improve its resistance to enzymes and oxidation. Those changes on their own extend the half-life to roughly thirty minutes.
CJC-1295 with DAC takes the idea a step further. An extra lysine at the chain's end carries a reactive maleimide group known as the drug affinity complex. In plasma this group bonds covalently to a free cysteine on serum albumin, after which the peptide travels around attached to a protein that persists for weeks. Teichman and colleagues ran human studies in 2006 in which one dose increased mean GH several times over for at least six days. It also kept IGF-1 raised for more than a week, with an estimated half-life of 5.8 to 8.1 days. Later work by Ionescu and Frohman found that GH pulses were maintained even as trough levels climbed. Researchers can buy CJC-1295 with DAC online in Australia as a 5 mg vial, with a certificate for every lot.
Order the Correct CJC-1295 for Sale, Why the Names Get Mixed Up
Technically, "CJC-1295" began as the development code for the DAC molecule. Over time sellers started using "CJC-1295 no DAC" as an alternative label for Mod GRF (1-29), so one phrase now covers two separate compounds. Before ordering CJC-1295 for any protocol, confirm which version the source paper actually used. Signs of the DAC version include the words "drug affinity complex", a half-life given in days, and administration spaced a week or more apart. Research on pulsatile GH release, brief sampling windows or combinations with a GHRP nearly always refers to Mod GRF. Order CJC-1295 no DAC online in Australia as a 10 mg vial when your design depends on those brief, separate pulses.
Our product pages are organised the same way. The CJC-1295 no DAC 10 mg vial contains Mod GRF (1-29), while the CJC-1295 DAC 5 mg vial holds the albumin-binding version. Every label names the version, and the certificate of analysis confirms identity by mass, which tells the two apart easily since the DAC contributes about 280 g/mol.
Buy CJC-1295 Online to Suit Your Study Design
Our recommendation is to begin with your sampling plan rather than with the compound. When GH will be sampled every 10 to 20 minutes to capture individual pulses, the DAC form raises the baseline for a week and smears the signal, making Mod GRF the better choice. When the endpoint is IGF-1 or some other slow-moving marker tracked across days, the DAC form delivers steadier exposure with fewer administrations.
| Study question | Stronger choice | Reason |
|---|---|---|
| Timing and amplitude of pulses | No DAC | A brief half-life keeps every pulse separate |
| IGF-1 tracked over one to two weeks | With DAC | One administration provides lasting exposure |
| Combined effect with a GHRP | No DAC | Its timing matches the brief action of ipamorelin |
| Crossover studies | No DAC | Washout takes hours rather than weeks |
| Minimal handling | With DAC | Weekly schedules instead of daily ones |
Many protocols underestimate washout. Because the half-life runs to several days, a DAC arm can take weeks to return to baseline, which slows crossover designs considerably.
Shop Growth Hormone Peptides Online, the Wider GHRH Family
Each version belongs to the same group as sermorelin, the unaltered GHRH (1-29) sequence whose half-life is measured in minutes, and tesamorelin, a full-length GHRH (1-44) analogue stabilised by a trans-3-hexenoyl group at its N-terminus. Think of sermorelin as the benchmark for near-native pulsatile signalling, Mod GRF as its sturdier relative, tesamorelin as the one with the most clinical study, and CJC-1295 with DAC as the long-acting exception. All four are listed together in our growth hormone peptides category. Shop sermorelin online from our Australian stock as a 10 mg vial when a study needs the unaltered GHRH sequence.
Order CJC-1295 and Ipamorelin Together
GHRH analogues and ghrelin receptor agonists work through separate receptors on the same pituitary cells, so their signals stack. Ipamorelin is the GHRP paired with Mod GRF most often, since published research shows it is selective for GH release with minimal effect on cortisol or prolactin. Both act briefly, so their timing matches. For protocols with a fixed ratio, our CJC-1295 and ipamorelin blend contains 5 mg of each in a single 10 mg vial. For dose-response studies, order separate vials so you can adjust each compound independently. Our guide to CJC-1295 and ipamorelin side effects summarises what the human studies show for both. The CJC-1295 and ipamorelin blend is for sale in Australia as one 10 mg vial for protocols that pair them.
Buy Supplies for Reconstitution and Storage
Each form ships as a lyophilised powder. Reconstitute it using bacteriostatic water, letting the liquid run slowly down the inside of the vial and swirling gently instead of shaking, and follow the full method in our peptide reconstitution guide. Our CJC-1295 and ipamorelin calculator gives concentration and syringe units for any fill, and insulin syringes help with measuring small volumes. Store dry vials frozen and away from light, then refrigerate after mixing, as explained in the peptide storage guide. When a vial arrives, match its lot number to the COA, and see our guide to reading a certificate of analysis for what to look at.
Buy CJC-1295 With or Without DAC Online in Australia
After you have decided on half-life, choosing the vial takes moments. CJC-1295 No DAC, which is Mod GRF (1-29), is sold as a 10 mg vial, and CJC-1295 With DAC is sold as a 5 mg vial. Order the No DAC form for pulsatile designs, and the DAC form for studies that need prolonged GHRH receptor exposure from occasional additions. If you are running a fixed ratio with a ghrelin receptor agonist, the CJC-1295 and ipamorelin blend spares you from preparing two vials. We hold all three in Australian stock, an independent laboratory tests every lot, and the certificates are kept in our COA library. Browse the growth hormone peptide range online and add bacteriostatic water to the same cart.
Every CJC-1295 product is sold to adults 18+ for laboratory research use only. None is approved by the TGA, and none is intended for human or veterinary use.
CJC-1295 DAC vs No DAC: Comparing the Two Versions for Research FAQ
How does CJC-1295 DAC differ from CJC-1295 no DAC?
The DAC form includes a drug affinity complex that attaches to serum albumin, which gives it a reported half-life of roughly 6 to 8 days. Both forms are GHRH analogues, so what really separates them is how long one administration remains active.
Are CJC-1295 no DAC and Mod GRF 1-29 the same compound?
Yes. CJC-1295 no DAC is simply the trade name used for Modified GRF (1-29), a GHRH analogue of 29 residues carrying four substitutions that help it resist enzymatic breakdown. The original CJC-1295 code belonged to the DAC molecule, hence the confusion. Look for any mention of the drug affinity complex in a study before picking your vial.
Which form of CJC-1295 is paired with ipamorelin?
Research on CJC-1295 with ipamorelin mostly uses the no DAC form, Mod GRF (1-29). Because both compounds act briefly, their release timing matches and the GHRH and ghrelin receptor signals merge into one pulse. Our ready-mixed blend holds 5 mg of CJC-1295 no DAC plus 5 mg of ipamorelin in a 10 mg vial.
How long does CJC-1295 with DAC stay active?
Teichman and colleagues' 2006 human pharmacokinetic study estimated the half-life of CJC-1295 with DAC at 5.8 to 8.1 days. One dose held GH above baseline for at least six days and lifted IGF-1 for more than a week. Allow washout periods of several weeks in crossover designs that use the DAC form.
Where do I order CJC-1295 DAC and no DAC online in Australia?
Both forms are available online from NovaPep out of Australian stock, CJC-1295 No DAC as a 10 mg vial and CJC-1295 With DAC as a 5 mg vial. Every batch has its identity and purity confirmed by an independent lab, and the matching report is filed in the COA library under the lot number on the label. Both are supplied for in-vitro and laboratory research, not for use in people or animals.