CJC-1295 With DAC 5 mg lyophilised peptide vial with purple flip-off cap and white label

NovaPep

Buy CJC 1295 With DAC Australia: CJC-1295 DAC 5mg Research Vial

$79AUD, GST included

In stock in Australia, batch certificate ready

Size: 5 mg vial

Certificate of analysis published for every batch
Third-party HPLC purity and MS identity testing
Dispatched same day before 3pm cut-off, tracked Australia-wide
Research use only, sold to adults aged 18 and over

Buy CJC 1295 with DAC online in Australia as a 5 mg research vial, tested for identity and purity on every lot. CJC 1295 with DAC is a long-acting GHRH analogue that starts from the Mod GRF (1-29) core, adds four protective substitutions, and finishes with a C-terminal lysine bearing maleimidopropionic acid. That drug affinity complex links to serum albumin, so the peptide's reported half-life stretches to days rather than minutes. Identity details are C165H269N47O46, 3647.2 g/mol and CAS 863288-34-0. Every batch is confirmed by mass spectrometry and quantified by HPLC, and you can read its certificate in the COA library before paying. Use the peptide calculator to turn any diluent volume into a working concentration. If your design contrasts a brief pulse with a sustained signal, put CJC-1295 No DAC in the same cart. Only powder is in the glass, so include bacteriostatic water with your order, and keep the closed vial frozen at -20 °C out of the light. Supplied as a research reagent for in vitro laboratory use, to buyers aged 18 or older.

For laboratory research use only. Not for human or veterinary use. Not TGA approved. See the NovaPep research use policy.

What Is CJC-1295 With DAC?

Think of CJC-1295 DAC as a stabilised piece of growth hormone releasing hormone carrying a small chemical anchor. That anchor grips albumin, the most plentiful protein in plasma, so its signal lasts for days rather than minutes. The anchor is the drug affinity complex, or DAC. Remove it and you are left with the identical receptor-binding chain that we sell as the No DAC version. CJC-1295 with DAC is for sale in Australia as a 5 mg research vial, ready to order online from local stock.

Inside the CJC-1295 DAC Molecule

At its heart sits Mod GRF (1-29), the opening 29 residues of human GHRH carrying four substitutions that resist enzymes. These are D-alanine at position 2, glutamine at 8, alanine at 15 and leucine at 27. A lysine at the C-terminus then holds the maleimidopropionyl group. This takes the conjugate to 3647.2 g/mol, roughly 280 g/mol more than the 3367.9 g/mol No DAC peptide. That mass difference is the fastest way to distinguish two white powders that look the same.

Where CJC-1295 DAC Comes From

This is the original long-acting version of Mod GRF (1-29). ConjuChem, a biotechnology company based in Montreal, created the drug affinity complex in the early 2000s to extend how long short peptides circulate. Fitting it to a stabilised GHRH fragment gave rise to CJC-1295 With DAC.

CJC-1295 DAC at a Glance

Core: Mod GRF (1-29) with four protective substitutions
Anchor: a C-terminal lysine carrying maleimidopropionic acid, the DAC
Identity: 3647.2 g/mol, CAS 863288-34-0
Developer: ConjuChem of Montreal, early 2000s
Reported half-life: about six to eight days

The Science Behind CJC-1295 DAC: How the Albumin Hook Works

The Chemistry of the Drug Affinity Complex

A maleimide ring forms the reactive tip of the anchor. Maleimides combine rapidly and selectively with thiols, the sulphur-hydrogen groups on cysteine, producing a durable thioether link. Of the 35 cysteines in human serum albumin, 34 are tied up in disulfide bridges, so the lone free thiol at position 34 is the natural partner. When the maleimide group contacts albumin it bonds covalently to that cysteine, and from then on the peptide travels with its carrier. Shop CJC-1295 with DAC online in Australia for this research, knowing each lot has been checked for identity and purity.

Albumin is plentiful, around 35 to 50 grams per litre of plasma, and a recycling receptor protects it from degradation, which gives it a half-life near three weeks. Whatever attaches to it shares that longevity, so in practice the peptide borrows albumin's lifespan.

Same Receptor, Different Exposure

The target receptor does not change. CJC 1295 with DAC engages the GHRH receptor on somatotrophs in the same way the short form does. That receptor is Gs-coupled and signals via cAMP. The difference lies in exposure, because the receptor sees a constant presence rather than short bursts. That raises the baseline of growth hormone release while natural pulses continue on top.

CJC-1295 DAC Research: From Albumin Conjugates to Clinical Trials

This concept was tested ahead of any human work. Jetté and co-workers, publishing in Endocrinology in 2005, coupled maleimide derivatives of GRF 1-29 to human albumin in vitro. They demonstrated that the conjugates withstood DPP-4 while still prompting growth hormone release from cultured rat pituitary cells, and they put forward CJC-1295 as the long-acting lead.

A year later Alba and colleagues used GHRH knockout mice to ask whether the conjugate could replace the absent hormone across weeks of treatment. Pharmacokinetic reports from 2005 and 2006, the Teichman study among them, put the half-life at about six to eight days, compared with a few minutes for native GHRH.

The compound started life as a clinical candidate. ConjuChem recruited 192 people with HIV-associated visceral obesity into a placebo-controlled phase 2 trial. It halted the trial in July 2006 following the death of a participant at an Argentinian site. The treating physician attributed the death to coronary artery disease and not to the drug, yet the programme was never restarted and nothing reached the market.

Working With the Conjugate in the Lab

This creates a sharply defined lab question. How do pituitary somatotrophs respond when their GHRH receptor is driven continuously rather than in pulses? A frequently overlooked detail follows. The extended half-life belongs to plasma and not to the vial. Serum-free culture medium contains no albumin to bind, so there the conjugate acts much like a short GHRH analogue.

Medium containing fetal bovine serum lets the maleimide capture bovine albumin instead, since that protein also has a free cysteine. Thiol reagents including DTT, 2-mercaptoethanol or surplus free cysteine will use up the maleimide before it reaches any protein, so leave them out of preparation buffers. Our full half-life comparison of both CJC-1295 forms shows how each one fits a sampling plan.

Reading the CJC-1295 DAC Evidence

The core findings date from the mid-2000s. In vitro work established that albumin conjugates resist DPP-4 and still signal at the pituitary. Pharmacokinetic studies established the long half-life. The clinical programme then stopped, so no later body of trial data exists. Most open questions are mechanistic, such as how continuous receptor exposure differs from pulses.

CJC-1295 With DAC Specifications

Product name	CJC-1295 With DAC (CJC-1295 DAC)
Size	5 mg vial
Structure	Analogue of GHRH (1-29) carrying D-Ala2, Gln8, Ala15 and Leu27, finished with a C-terminal lysine that holds maleimidopropionic acid (the drug affinity complex)
Chain length	29 amino acid GHRH core plus the DAC lysine
Formula	C165H269N47O46
Molar mass	3647.2 g/mol
CAS	863288-34-0
Physical form	Lyophilised powder in a sealed 3 mL glass vial with a purple flip-off cap
Quality testing	Mass spectrometry for identity, HPLC for purity, a certificate for every lot
In the box	A single vial containing 5 mg of CJC-1295 With DAC, no diluent included (bacteriostatic water sold separately)
Storage conditions	Closed vial at -20 °C, kept dry and dark, and reconstituted solution at 2 to 8 °C
Stock status	In stock
Intended use	In vitro laboratory research only

You receive one 5 mg vial sealed under a purple flip-off cap, holding the conjugate as dry white powder with no diluent, carrier or second peptide inside. Its fill is half that of the No DAC vial on purpose. A compound that remains attached to albumin for days needs much less material over a study series than a short-acting analogue would. The added synthesis step, coupling and then purifying the maleimide linker, also makes the DAC form more demanding to produce.

Before reordering, confirm three points on the certificate. You want a measured mass that matches the DAC molecule, the CAS 863288-34-0, and an HPLC purity result tied to the lot number on your vial. Each report lives in the COA library, and our guide to reading a certificate of analysis walks through every line.

Handling and Storage of CJC-1295 DAC

Because the maleimide group hydrolyses slowly in water, especially as pH rises, reconstitute only once you are ready to start. Bring the vial to room temperature, let bacteriostatic water run down the glass wall, and swirl softly without shaking. Two millilitres added to the 5 mg vial produces 2.5 mg/mL. The peptide calculator covers other volumes, and our reconstitution guide explains aseptic technique. CJC-1295 with DAC for sale in Australia leaves our shelves by tracked post, so it reaches your bench in good condition.

Keep the sealed powder at -20 °C inside its carton, shielded from light and moisture. After dissolving, store the solution at 2 to 8 °C and use it within 28 days, preferably divided into single-use aliquots so the stock avoids repeated warming.

CJC-1295 DAC Compared With No DAC

The two forms share an identical Mod GRF core and differ only in the linker. The DAC version lasts for days and fits designs that need sustained elevation. CJC-1295 No DAC, by contrast, clears in around 30 minutes, tracks the natural pulse more closely and is sold as a 10 mg vial. Running both lets you isolate what albumin binding does while the receptor-binding sequence stays fixed.

For other options, Tesamorelin retains the complete 44 residue GHRH chain, while ipamorelin acts through the ghrelin receptor and not GHRHR. If your lab also wants the No DAC core with ipamorelin, the CJC-1295 and ipamorelin blend suits paired study designs. The DAC versus No DAC comparison covers half-life, fill size and the designs each form suits.

Other Names for CJC-1295 With DAC

Catalogues may call this compound CJC-1295 DAC, long-acting CJC-1295 or just DAC CJC. Earlier papers describe it as a GRF (1-29) analogue conjugated to a drug affinity complex, or as a GHRH analogue that binds albumin. All of these refer to one 29 residue core with a lysine-linked maleimide, registered as CAS 863288-34-0.

Knowing the receptor terms is useful as well. GHRH means growth hormone releasing hormone, also written GRF or somatocrinin, and its receptor is shortened to GHRHR. The downstream readout most studies follow is IGF-1, insulin-like growth factor 1, which the liver makes when growth hormone stimulates it.

Buy CJC 1295 With DAC Online in Australia

Australian law identifies this exact molecule. The Poisons Standard entry "CJC-1295 (CAS No. 863288-34-0)" carries the same CAS number shown on our certificates. As of October 2026, under the June 2026 instrument, the entry appears in Schedule 4 as a prescription-only medicine and in Appendix D, clause 5, so possessing it without authority is illegal. The listing came out of the TGA's 2014 to 2015 review of growth hormone releasing peptides and related substances. There is still no ARTG-registered product a prescriber could select, which is why CJC-1295 DAC in Australia is encountered almost only as a research chemical.

Whether a design needs CJC 1295 DAC or no DAC depends on how long the signal should last, since the DAC version binds albumin and stays active far longer.

Class S2 of WADA's 2026 Prohibited List names CJC-1295 among the GHRH analogues. Sport Integrity Australia tests against that list, and the prohibition applies both in and out of competition.

NovaPep stocks CJC-1295 With DAC in Australia as a laboratory reagent for adults aged 18 or over, for in vitro research only and never for human or veterinary use. It sits with the other secretagogues in our growth hormone peptides collection. Buyers confirm their age and agree to the research use policy before paying. Several vials in a single checkout ship from one lot wherever stock permits, so plan the full sampling schedule first and order the whole quantity together.

NovaPep has no shopfront or collection counter and supplies every state and territory from a single Australian stock. Labs looking for research peptides in Canberra use this page like everybody else. Orders paid before 3pm on a business day go out that afternoon, and the vial, lot and certificate are identical wherever your lab happens to be.

CJC-1295 With DAC at a Glance

GHRH Analogue With an Albumin Anchor

CJC-1295 With DAC is a stabilised 29 residue GHRH fragment carrying a maleimide group on a lysine. That group binds serum albumin and extends the reported half-life to six to eight days.

Borrowing Albumin's Lifespan

The maleimide bonds to the free cysteine at position 34 of albumin, a carrier protein with a half-life near three weeks.

Long Receptor Stimulation, Lab Use Only

Researched for extended GHRH receptor activation and for the pharmacokinetics of albumin conjugates. Sold for in vitro and laboratory research only.

Versus CJC-1295 No DAC

The same core sequence minus the linker, with a half-life near 30 minutes. No DAC suits pulse designs and With DAC suits sustained ones.

Mix It Just Before Use

Store the sealed vial at -20 °C. In water the maleimide group breaks down slowly, so reconstitute only when work starts and keep the solution at 2 to 8 °C in aliquots.

Buy the 5 mg Vial online

One sealed 5 mg vial from Australian stock, with mass spectrometry confirming the 3647.2 g/mol conjugate. Read the certificate in the COA library before you order.

CJC-1295 With DAC FAQ

How do laboratories use CJC-1295 With DAC?

Labs use it as a research reagent to study extended GHRH receptor activation, the GH and IGF-1 axis, and how albumin conjugation alters what happens to a peptide. It is not a medicine, has no TGA approval, and is sold only for in vitro and laboratory work to buyers aged 18 or over.

How does the DAC extend the half-life of CJC-1295?

The drug affinity complex is a maleimide group on a C-terminal lysine. It bonds covalently to the free cysteine at position 34 of serum albumin, so the peptide shares albumin's long circulation. In serum-free culture medium there is no albumin to bind, so the effect does not apply there.

Should I buy CJC 1295 with DAC or without DAC?

Pick With DAC if your study needs GHRH receptor stimulation held over several days, as albumin binding gives a reported half-life of six to eight days. Pick No DAC, the 10 mg Mod GRF (1-29) vial, for short pulse designs or for pairing with ipamorelin. Plenty of labs order both for a direct comparison.

Is a certificate of analysis supplied with CJC-1295 With DAC?

Yes. Mass spectrometry confirms the 3647.2 g/mol DAC conjugate in each lot and HPLC measures its purity, with the certificate filed under the lot number on your vial. View it in the COA library before buying, which is important because the DAC and No DAC powders cannot be told apart by eye.

What is the CJC 1295 with DAC dosage?

NovaPep gives no dosage of CJC 1295 with DAC for people or animals, because the 5 mg vial is sold for laboratory research only. Any question about CJC-1295 with DAC dosing sits outside a research supplier's role. For bench work, the peptide calculator converts the 5 mg fill and your diluent volume into a working concentration.

What are the steps to order CJC 1295 with DAC online in Australia?

Place the 5 mg vial in your cart on this page and go through checkout. It leaves from Australian stock, and payment before 3pm on a business day means it goes out that afternoon with tracking. Transit times appear on our delivery information page. Add bacteriostatic water to the same order, since the vial holds only powder.