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Buy Epitalon Australia: Epitalon 10mg and 50mg Research Vials (Ala-Glu-Asp-Gly)

$45AUD, GST included

In stock in Australia, batch certificate ready

Certificate of analysis published for every batch
Third-party HPLC purity and MS identity testing
Dispatched same day before 3pm cut-off, tracked Australia-wide
Research use only, sold to adults aged 18 and over

Buy Epitalon online in Australia in 10 mg and 50 mg research vials, tested for identity and purity on every lot. Epitalon peptide, sometimes spelled epithalon and shortened to AEDG, is the synthetic tetrapeptide Ala-Glu-Asp-Gly. Vladimir Khavinson's St Petersburg team designed it as a defined replacement for epithalamin, an extract of the pineal gland, and it appears chiefly in telomerase and cellular ageing research. The identity figures you can verify are C14H22N4O9, 390.3 g/mol and CAS 307297-39-8. Mass spectrometry confirms every lot and HPLC measures its purity, and you can open the certificate of analysis before checkout. Convert any diluent volume into a concentration with the peptide calculator, and add Pinealon to the same order if you want two bioregulators side by side. The powder ships dry without diluent, so include bacteriostatic water in your cart, and store the closed vial at -20 °C out of the light. Supplied as a research reagent to adults aged 18 or older.

For laboratory research use only. Not for human or veterinary use. Not TGA approved. See the NovaPep research use policy.

What Is Epitalon?

Only four amino acids long, Epitalon is a synthetic peptide studied as a potential trigger for telomerase, the enzyme that restores the protective caps at the ends of chromosomes. It belongs to a group the Russian literature calls bioregulators, which are very short chains of two to four residues thought to influence gene expression instead of acting through a conventional receptor on the cell surface. Epitalon is for sale in Australia as a 10 mg or 50 mg research vial, ready to order online from local stock.

Physically, Epitalon is a sealed glass vial containing a small white lyophilised cake of 10 mg or 50 mg of the AEDG tetrapeptide, shipped dry so the lab can pick its own diluent. Its sequence goes back to epithalamin, a polypeptide preparation from bovine pineal gland that Khavinson's team investigated at the Kirov Military Medical Academy in Leningrad starting in the early 1980s. In 1992 Khavinson founded the St Petersburg Institute of Bioregulation and Gerontology, and the four-residue synthetic came next as a way to work with one defined molecule rather than an inconsistent gland extract. Having one characterised structure is precisely what gives a per-lot certificate its meaning.

Inside the AEDG molecule

AEDG is a small, highly polar molecule. Its two acidic residues, glutamate and aspartate, are flanked by alanine at the N-terminus and glycine at the C-terminus, which is why the powder goes into water-based diluents so easily. It has no protecting groups, which distinguishes it from N-acetyl epitalon amidate, a capped analogue of higher mass that we do not carry.

How Epitalon Is Thought to Work

Whenever a typical human cell divides, its telomeres, which are runs of the TTAGGG repeat at each chromosome tip, become slightly shorter. Telomerase can restore those repeats, but in most adult somatic cells hTERT, the gene for its catalytic subunit, is scarcely switched on, so the caps erode until division stops. The theory behind AEDG is that it pushes hTERT expression higher. Exactly how such a tiny molecule could do that remains unresolved. The originating group proposes that short peptides enter the nucleus and attach to particular DNA sequences in promoter regions, an idea based largely on molecular modelling and their own cell results rather than a recognised mechanism.

Epitalon Research: What Studies Have Looked At

Epitalon is the best documented of the short bioregulators produced by Vladimir Khavinson's school at the St Petersburg Institute of Bioregulation and Gerontology. During the 1980s the team worked with epithalamin, a crude polypeptide extract from bovine pineal gland, and later made the four-residue sequence Ala-Glu-Asp-Gly synthetically to capture part of that activity in one defined molecule. A heavily cited 2003 paper described telomerase activation and telomere lengthening in cultured human fibroblasts, and that report still shapes the core question of whether so small a peptide can alter gene expression linked to cellular ageing. Shop Epitalon online in Australia for this research, knowing each lot has been checked for identity and purity.

The most significant independent evidence appeared in 2025 in Biogerontology. A Brunel University London team found longer telomeres, rising with dose, in two normal cell types, IBR.3 fibroblasts and human mammary epithelial cells, and traced the effect to upregulated telomerase. Treatment ran for three weeks at concentrations of 0.1 to 1 µg/mL. By contrast, the breast cancer lines 21NT and BT474 extended their telomeres through another route, alternative lengthening of telomeres (ALT), and the journal subsequently published a correction that replaced three figures.

Most animal data come from Vladimir Anisimov's team at the Petrov Institute of Oncology. Their 2003 study in female SHR mice, with 54 animals per group, found no change in mean lifespan, body weight or overall tumour incidence among treated mice. Even so, the longest-lived 10 per cent survived 13.3 per cent longer, maximum lifespan increased by 12.3 per cent, leukaemia was six times rarer, and bone marrow chromosome aberrations dropped by 17.1 per cent.

In our view that mouse study is the most frequently misquoted. What it showed was a longer tail of survivors, not a longer average lifespan. Anyone planning an ageing study should settle at the outset whether the endpoint is telomere length, hTERT transcript level or survival, since the cell research has answered the first two more clearly. For telomere length measures such as qPCR or TRF blots, allow at least three weeks of exposure, matching how long the Brunel cultures ran before measurement.

Subsequent studies from the same group examined night-time melatonin rhythms in aged rodents and primates and lifespan markers in rodents and fruit flies, while a more recent hypothesis suggests very short peptides interact with chromatin. Independent replication remains limited, which is exactly why lot-tested material is important. It sits in our longevity peptides collection beside the other Khavinson sequences, offered as a research reagent with no link to any medicine.

Fibroblast and skin cell research

Interest in the skin benefits of Epitalon peptide stems entirely from in vitro research, not from any use on people. The fibroblast telomerase findings, along with later studies of dermal cell senescence markers and collagen-related gene expression, established AEDG as a reference tetrapeptide for labs growing skin-derived cells. It suits that sort of bench work, where you can set a defined four-residue chain against matrix gene panels, senescence staining or the passage number of the culture. Skin-derived cells age visibly in a dish, which makes them a practical model for this kind of comparison.

Epitalon Specifications

Product name	Epitalon (epithalon, AEDG)
Sizes	10 mg vial, 50 mg vial
Sequence	Ala-Glu-Asp-Gly, a linear tetrapeptide ending in a free C-terminal acid
Residue count	4 amino acids
Formula	C14H22N4O9
Molar mass	390.3 g/mol
CAS	307297-39-8
Physical form	Lyophilised powder inside a sealed glass vial with a flip-off cap
Quality testing	Mass spectrometry for identity, HPLC for purity, a certificate of analysis on every lot
In the box	A single vial of Epitalon powder (10 mg or 50 mg) with no diluent, bacteriostatic water sold separately
Storage conditions	Closed vial at -20 °C, kept dry and away from light. Reconstituted at 2 to 8 °C
Stock status	In stock
Intended use	In vitro laboratory research only

Two fills make planning simple for cell ageing work, with the 10 mg vial suited to a pilot and the 50 mg vial suited to long culture series at a much lower price per milligram. Both are stocked in Australia, and every batch comes with a certificate of its own.

When reviewing the certificate, check for a measured mass consistent with 390.3 g/mol and an HPLC trace led by a single main peak, with purity reported for that exact lot. Every certificate is posted in the COA library under the lot number on the vial label, so the paperwork you keep matches your powder.

Handling and Storage of Epitalon

Only powder is in the vial. Allow it to warm to room temperature, run the diluent slowly down the inner wall of the glass and swirl softly instead of shaking. For a 5 mg/mL stock, put 2 mL of bacteriostatic water into the 10 mg vial or 10 mL into the 50 mg vial. Any other volume can be worked out with our peptide calculator. Epitalon for sale in Australia leaves our shelves by tracked post, so it reaches your bench in good condition.

Unopened, the vial keeps at -20 °C in dry, dark conditions, and the dry cake copes with a short time at room temperature during transit. After dissolving, store the solution at 2 to 8 °C, split into aliquots so each one is thawed just once.

Epitalon Compared With Pinealon and Other Bioregulators

Although both are Khavinson bioregulators, they address different questions. Epitalon, with four residues, turns up mostly in models of fibroblast, pineal and telomerase ageing. Pinealon is a three-residue chain, Glu-Asp-Arg, used largely in neuronal cultures exposed to oxidative stress. If you are tracking ageing markers in dividing cells, Epitalon is the one to choose. For neuronal endpoints go with Pinealon, and order the pair when one project calls for two sequences from that school.

For a closer structural control, add Cartalax, which is AEDG minus its last glycine. In pineal rhythm and sleep work, labs most often group DSIP, Epitalon and Pinealon together, so DSIP is a sensible addition when melatonin timing forms part of the design.

Best peptides for sleep, DSIP, Epitalon, Pinealon: which suits my study?

Each covers a different angle. DSIP is studied in sleep pattern research, Epitalon in pineal and melatonin models, and Pinealon in neuronal cell work. Labs building a sleep panel often order all three, each with its own lot certificate.

Other Names for Epitalon

Epitalon and epithalon are simply two transliterations of the same Russian name, and both refer to the tetrapeptide offered here. You will also meet the one-letter code AEDG in research papers, as well as the systematic name L-alanyl-L-glutamyl-L-aspartyl-glycine. Earlier literature describes it as the synthetic analogue of epithalamin, sometimes spelled epitalamin, the pineal extract it was built to replace. Whatever name appears, the identity markers remain CAS 307297-39-8 and the formula C14H22N4O9.

Buy Epitalon Online in Australia, Fills, Delivery and Legal Status

The 10 mg vial is a good fit for solubility checks, an initial concentration series in a new cell line or a brief pilot. The 50 mg vial cuts the cost per milligram well below the smaller fill and lets a lengthy senescence or telomerase project stay on a single batch. Both fills are produced to an identical specification, so switching between them partway through does not change the compound you are testing.

Order several vials at once and they leave from one lot under one certificate wherever stock allows, so your notebook stays consistent when you line up results many months down the track. Only buyers who confirm at checkout that they are 18 or above can purchase Epitalon.

There is no medicines pathway for Epitalon in Australia. As of October 2026 the Poisons Standard does not name the compound anywhere, which we confirmed against the October 2026 instrument, so no schedule applies. Being unscheduled is not the same as being approved, however. The TGA regards a peptide supplied for therapeutic use without an Australian Register of Therapeutic Goods entry as an unapproved product, and unapproved peptides are now one of its compliance priorities. That leaves the research market as the normal supply route, which is why anyone looking for Epitalon peptide Australia stock lands on reagent suppliers and not clinics or dispensaries.

NovaPep holds both Epitalon Australia fills in local inventory, sold as a laboratory research reagent to adults aged 18 or over and never for human or veterinary use. When a lab sets several Khavinson peptides against each other, Thymalin, the thymic bioregulator from the same programme, is a common companion, and the research use policy explains the conditions that apply to every order.

NovaPep has no shopfront or collection counter. We operate entirely online and send tracked parcels to every state and territory from Australian stock. Labs looking for research peptides in Melbourne draw on the same certified lots as all other buyers, orders paid before 3pm on a business day go out that afternoon, and our delivery information page sets out the timings.

More on Buying Epitalon in Australia

Which Epitalon fill offers the best value?

The 50 mg vial does. It works out far cheaper per milligram than the 10 mg vial. The smaller vial is still sensible for a pilot or a solubility test, as it limits how much powder is left idle if a project is put on hold.

Epitalon at a Glance

Pineal bioregulator with four residues

Epitalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly, built to reproduce part of the activity of the pineal extract epithalamin.

Buy Epitalon in 10 mg or 50 mg Online

One sealed vial of lyophilised powder, in 10 mg or 50 mg. The vial ships without diluent, so add bacteriostatic water to your cart.

Telomerase and skin cell research

Investigated in cultured fibroblasts, in pineal rhythm studies of aged animals and in gene expression work, strictly at the lab bench.

Compared with Pinealon

Pinealon comes from the same research school but is a tripeptide used in neuronal studies. Epitalon stays the reference sequence for telomerase research.

Freeze sealed, refrigerate mixed

Store the closed vial at -20 °C. After dissolving, keep it in the fridge in single-use aliquots and do not refreeze.

Tested every lot

Identity is confirmed by mass spectrometry, purity is measured by HPLC, and each certificate is posted in the COA library.

Epitalon FAQ

What is Epitalon and how is it thought to work?

Epitalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly, made by Khavinson's group to replace the pineal extract epithalamin. The working theory is that it raises expression of hTERT, the catalytic subunit of telomerase, in cultured cells. How such a small molecule could do that is still unresolved.

What are the steps to order Epitalon online in Australia?

Pick the 10 mg vial or the 50 mg vial on this page, place it in the cart and finish checkout. Because stock is kept in Australia, orders paid before 3pm on a business day ship that afternoon. Only powder is in the vial, so add bacteriostatic water to your order if your lab has no diluent available.

Will Epitalon arrive with a certificate of analysis?

It will. Before release, every lot is tested by mass spectrometry for identity and by HPLC for purity, and the certificate is posted in the COA library. The lot number on your vial label corresponds to that certificate, so you can store the exact document alongside your experimental records.

Which is better for my study, Epitalon or Pinealon?

Epitalon fits telomerase, fibroblast ageing and pineal models, as most of the bioregulator research in those areas uses the AEDG tetrapeptide. Pinealon, the tripeptide Glu-Asp-Arg, fits neuronal culture studies on oxidative stress. Ordering both allows one study to compare two sequences from the same research programme.

How do laboratories use Epitalon?

Researchers treat this defined four-residue chain, Ala-Glu-Asp-Gly, as a tool for ageing studies in animal models and cultured cells, including dermal fibroblasts. The aim is usually to find out whether such a short peptide can shift gene expression or telomerase activity. It is sold only for in vitro research and never for human or veterinary use.

What are the Epitalon peptide benefits for skin, before and after?

There are no reliable before and after results to show. Searches for Epitalon peptide benefits for skin lead back to cell studies on fibroblasts and telomerase, not to tested outcomes in people. We make no cosmetic claims, and the vial is sold for in vitro research only.