Pinealon 10 mg lyophilised peptide vial with white cap and pink and blue label

NovaPep

Buy Pinealon Australia: Pinealon 10mg Research Vial

$50AUD, GST included

In stock in Australia, batch certificate ready

Size: 10 mg vial

Certificate of analysis published for every batch
Third-party HPLC purity and MS identity testing
Dispatched same day before 3pm cut-off, tracked Australia-wide
Research use only, sold to adults aged 18 and over

Buy Pinealon online in Australia as a 10 mg research vial of the Glu-Asp-Arg tripeptide, tested on every lot. Pinealon, supplied in Australia as a research reagent, is the tripeptide Glu-Asp-Arg, abbreviated EDR, among the shortest chains in the bioregulator series developed by Vladimir Khavinson's team in St Petersburg. It has no known receptor, and its developers propose that it enters cells and binds histones or RNA. It turns up mostly in neuronal culture work on oxidative stress and dendritic spines. Two fixed markers confirm its identity, the formula C15H26N6O8 and a molar mass of 418.4 g/mol. It comes as a 10 mg lyophilised vial of Pinealon peptide sent from local stock. Every batch is checked by HPLC for purity and confirmed by mass spectrometry, and you can read the lot certificate before paying. Work out how much diluent to use with the reconstitution calculator. Add Epitalon to the same parcel for a second bioregulator from the same research school. The vial contains a dry cake with no solvent, so put bacteriostatic water in your cart and keep the sealed vial frozen at -20 °C. Supplied as a laboratory research reagent to adults 18 and over only.

For laboratory research use only. Not for human or veterinary use. Not TGA approved. See the NovaPep research use policy.

What Is Pinealon?

Pinealon is a lab-made peptide of just three amino acids, used by researchers to test whether a molecule much smaller than a hormone or growth factor can still alter the behaviour of nerve cells. Most neuroactive peptides have a known receptor, but this one does not. That one point determines how the Pinealon peptide is investigated and how its findings ought to be interpreted. Buy Pinealon online in Australia as a 10 mg research vial, with the lot certificate published before you order.

Pinealon was developed in the same St Petersburg program behind Epitalon. Epitalon took its cue from a pineal extract, whereas Pinealon is a stripped-back three-residue design in which two negatively charged residues, glutamic acid and aspartic acid, come before a positively charged arginine. Thanks to that charge arrangement the molecule dissolves very easily in water and is straightforward to analyse.

How Pinealon Is Thought to Work

Typical signalling peptides bind a receptor at the cell surface and set off a chain of events inside. The team that created EDR suggests another pathway, in which the tripeptide is small enough to enter the cell and may then attach to histone proteins, the spools around which DNA is wound, or to RNA. A 2021 review in Molecules connected that binding to changes in MAPK/ERK signalling, which neurons depend on for survival and plasticity, and to altered expression of genes for apoptosis, antioxidant enzymes and transcription factors. Regard this as a working hypothesis from the developers, not a mechanism that independent groups have confirmed.

Pinealon Research: What Studies Have Looked At

The newer and more intriguing findings involve dendritic spines, the small projections on a neuron that host most excitatory synapses. Stable, mature spines have a rounded head, earning the name mushroom spines, and they disappear early in rodent models of Alzheimer's disease. In 2017 the same school reported that EDR at 200 ng/mL increased mushroom spine numbers by 71 per cent in mouse hippocampal cultures subjected to amyloid synaptotoxicity. A 2021 article in Pharmaceuticals went on to describe EDR, together with the related tripeptide KED, protecting against spine loss in 5xFAD-M transgenic mice, and the review notes comparable culture results in a Huntington's model. To run this kind of in vitro work, buy Pinealon online in Australia from lots tested by HPLC and mass spectrometry.

Pinealon is above all a neuronal research tool. Most published work uses cerebellar granule cell cultures under oxidative stress, measuring reactive oxygen species, cell viability and caspase-3 activity, along with rodent studies in the offspring of dams given experimental hyperhomocysteinaemia. The question it allows a lab to ask is tight and testable, namely whether a three-residue peptide alters how neurons deal with oxidative load. Being so small, it is also a low-cost way to check whether bioregulator effects hinge on chain length. It is listed as a reagent and not a medicine in our nootropic peptides range and among the longevity peptides.

The tripeptide came out of Khavinson's St Petersburg Institute of Bioregulation and Gerontology. Its most cited English-language paper, published in Rejuvenation Research in 2011, reported reduced reactive oxygen species and less necrotic cell death in cerebellar granule cells, neutrophils and PC12 cells under oxidative challenge.

What does a lab take from this? A low-cost, fully characterised and very soluble molecule, supported by literature that originates almost wholly from a single school. That justifies adding it to a study, but it does not justify expecting the reported effect sizes to replicate.

One recommendation for groups testing EDR on neurons is to commission a scrambled control from the same three residues, such as DER or RDE, from a custom synthesis provider and run it on the same plates. With no receptor available to block, a scrambled sequence is the neatest way to prove that changes in spine counts or viability rely on the order of the residues and not on additional glutamate, aspartate and arginine in the medium. Glutamate is itself an excitatory neurotransmitter, so leaving out that control in a neuronal assay invites an obvious criticism.

Pinealon Specifications

Product name	Pinealon (EDR)
Fill	10 mg vial
Sequence	Glu-Asp-Arg (H-Glu-Asp-Arg-OH), linear tripeptide
Chain length	3 amino acids
Formula	C15H26N6O8
Molecular weight	418.4 g/mol
Appearance	Freeze-dried powder in a sealed glass vial
Quality checks	HPLC for purity, mass spectrometry for identity, one certificate per lot
In the box	One 10 mg vial of Pinealon per unit, with no diluent supplied (bacteriostatic water purchased separately)
Storage conditions	Sealed at -20 °C, kept from light and moisture. After reconstitution at 2 to 8 °C
Stock status	In stock
Intended use	In vitro laboratory research only

Inside the carton is a single 10 mg glass vial with a white cap, with the powder settled as a pale, firm cake at the bottom. Base your concentration planning on the 10 mg stated on the label, and check the lot certificate for the purity behind that figure.

Pinealon fits a neuronal culture project that needs the smallest compound in the bioregulator family. The 10 mg vial is stocked in Australia, each batch carries a certificate, and a single fill covers a long series of plates.

Identity Without a CAS Number

Our records hold no verified CAS number for Pinealon, so identity is established by the formula C15H26N6O8 and the 418.4 g/mol mass. Expect the certificate to report a measured mass in line with that figure and an HPLC trace dominated by a single peak, together with the purity value for the lot.

EDR is short and carries a strong charge, so it comes off a reverse-phase HPLC column early, and another closely related tripeptide might appear almost identical on a chromatogram by itself. The mass data is what distinguishes it from similar sequences. Find any lot in the certificate library with the number printed on your label.

Handling and Storage of Pinealon

To reconstitute, let the vial reach room temperature, run the diluent gently down the glass and swirl until the liquid is clear. Putting 2.5 mL of bacteriostatic water into the 10 mg vial yields 4 mg/mL, and the peptide calculator handles any other volume in moments. When you buy Pinealon online in Australia, orders paid by 3pm on a business day are dispatched the same afternoon.

Store the unopened vial at -20 °C, dry and in the dark. Keep the solution refrigerated at 2 to 8 °C, preferably divided into aliquots so the main stock is not warmed and cooled repeatedly. Mark each tube with lot number, concentration and preparation date, so any later result can be linked directly to its certificate.

Pinealon Compared With Epitalon and Cartalax

Pinealon is the choice for neuronal endpoints such as oxidative stress, viability and apoptosis markers in cells derived from the brain. Epitalon, the four-residue AEDG peptide, is the choice for telomerase and pineal ageing models, where the bulk of bioregulator research is found. Each contains a Glu-Asp pair, the acidic core common to several Khavinson peptides, which makes them an obvious pairing for comparison on one cell line.

When assembling a broader bioregulator panel, Cartalax is a useful addition, as this AED tripeptide associated with cartilage research lets three related sequences be tested under the same conditions.

Other Names for Pinealon

Literature and supplier listings show Pinealon as EDR, Glu-Asp-Arg or H-Glu-Asp-Arg-OH, and written out fully as L-glutamyl-L-aspartyl-L-arginine. Russian sources place it among the synthetic peptide bioregulators, at times called cytogens, a class made up of chains between two and four residues long. All of these names point to the same 418.4 g/mol tripeptide. In any peptide catalogue the letters EDR mean this chain and only this chain, so the code by itself is enough to match a paper's reagent to our vial.

Is Pinealon Legal in Australia?

So is Pinealon legal in Australia? As of October 2026 it is not listed in the Poisons Standard (we checked the October 2026 instrument for the name), which means it has no schedule entry of its own. That is very different from being a medicine. Any peptide supplied for a therapeutic purpose must first be entered on the Australian Register of Therapeutic Goods, and the TGA has singled out unapproved peptide products for compliance action. As a result, Pinealon Australia supply in practice comes through laboratory reagent suppliers and not through any medical channel.

Buy Pinealon Online in Australia

When you buy Pinealon peptide from NovaPep, you are purchasing a research reagent kept in Australian stock and sold to adults aged 18 and over for in vitro and laboratory use only, never for human or veterinary use. For a neuronal panel that also explores sleep and pineal questions, DSIP, offered as a vial or spray, fits naturally alongside it, and our peptide storage guide explains how to keep a small tripeptide stable between runs.

We carry one size of Pinealon, a 10 mg vial. Having a single format keeps administration simple, with one vial type, one specification and one certificate for each batch.

Published neuronal cultures use low working concentrations, so a single 10 mg vial generally handles method development, a concentration-response series and a number of replicate plates. If your project will set Pinealon against other bioregulators, putting those vials in the same order keeps delivery, storage start date and records in step across the full panel.

Purchase every vial a replicated series is likely to need in one go, so that where stock permits they ship from one lot under one certificate. This avoids a batch change partway through, the variable most worth removing in small-peptide studies. Pinealon is supplied only to adults 18 and over, and checkout includes an age declaration.

You will not find a Pinealon counter to visit. NovaPep sells online only and ships from stock held here to any Australian address, and orders paid before 3pm on a business day are packed and sent that afternoon, as our delivery page explains. A lab ordering research peptides in Brisbane receives the same cold-packed vial as one in a country town.

Pinealon at a Glance

A three-residue EDR peptide

Pinealon is Glu-Asp-Arg, a bioregulator from Vladimir Khavinson's research program that dissolves easily because of its charged side chains.

Buy the 10 mg vial online

Each sealed 10 mg vial holds dry powder. It comes without solvent, so add bacteriostatic water to the order.

Oxidative stress in neurons

Applied in cerebellar granule cell cultures and rodent models measuring reactive oxygen species, viability and caspase-3, purely as a lab reagent.

Versus Epitalon

Epitalon is the four-residue AEDG peptide used in telomerase research. Pinealon is shorter and suited to neuronal endpoints.

Freeze first, then aliquot

Keep the sealed vial at -20 °C. Once reconstituted, store at 2 to 8 °C in small aliquots and avoid repeated freezing and thawing.

Mass and purity recorded

Every batch is confirmed by mass spectrometry and quantified by HPLC, and its certificate matches the lot printed on the label.

Pinealon FAQ

What is Pinealon and how is it thought to work?

Pinealon is the synthetic tripeptide Glu-Asp-Arg from the Khavinson bioregulator program. It has no known receptor. Its developers propose that it enters cells and binds histones or RNA, altering MAPK/ERK signalling and gene expression, a hypothesis that independent groups have not yet confirmed.

Can I buy Pinealon peptide near me?

Yes, online from any Australian city or regional centre. Put the 10 mg vial in your cart, and orders paid before 3pm on a business day are sent the same day. NovaPep has no retail store or pickup point, so every order comes from the same local stock and ships with order tracking to your door.

Is a certificate of analysis included with Pinealon?

Yes. Every lot is tested by HPLC for purity and by mass spectrometry to confirm the 418.4 g/mol mass, and the certificate is published in the COA library. Check the lot number on your vial against the report before beginning a series, and file a copy with your plate records.

Which should I buy, Pinealon or Epitalon?

Pinealon suits neuronal studies of oxidative stress, viability and apoptosis. Epitalon suits telomerase and cell ageing models in dividing cells. Since both share a Glu-Asp core, many labs buy a vial of each to compare bioregulator sequences on one cell system, all in a single parcel.

How is Pinealon used in laboratory research?

Pinealon is the synthetic tripeptide Glu-Asp-Arg, used as a reagent in rodent research and neuronal cultures. It allows a lab to examine whether a very short peptide alters how cells respond to oxidative stress. It is sold for in vitro research only and is never meant for people or animals.

Can Pinealon be legally bought in Australia?

As of October 2026 the Poisons Standard does not name Pinealon, so it carries no schedule of its own. It is not an approved medicine either, and the TGA does not permit unapproved peptides to be supplied for therapeutic use. NovaPep sells it solely as a laboratory research reagent to adults 18 and over, not for human or veterinary use.